Human MDR1 N and C termini alaignment

       1 MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY 50
               |.    .    ||. |   |  |  | || . . :  |  :  |
       1 ...STRRSVRGSQAQDRKLSTKEALD..ESIPPVSFWRIMKL.NLTEWPY 44
                  .         .         .         .         .
      51 MVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDIND 100
          |||   |||.|   |   ::| ..  :|    . |      | | . | 
      45 FVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPE......TKRQNSN. 87
                  .         .         .         .         .
     101 TGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHK.IRK 149
                      :.  :  :|    :  ::|  |    ||  : | :| 
      88 ............LFSLLFLALGIISFITFFLQ.GFTFGKAGEILTKRLRY 124
                  .         .         .         .         .
     150 QFFHAIMRQEIGWFD..VHDVGELNTRLTDDVSKINEGIGDKIGMFFQSM 197
           | ..:||:: |||   .  | | ||| .| ..:   || :: .  |..
     125 MVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI 174
                  .         .         .         .         .
     198 ATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAY 247
         |   || |: |  ||.|||.:||| |:: :.  |  |.||    |:    
     175 ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKEL 224
                  .         .         .         .         .
     248 AKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANI 297
           || :| | :   |||:.   :.|    | ..|:   |  ::||    |
     225 EGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGI 274
                  .         .         .         .         .
     298 SIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQ 347
         .      :.| |||  | :|  ||     |   || || .|. || .|||
     275 TFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQ 324
                  .         .         .         .         .
     348 ASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNV 397
          |     :| |: .|  |  ||:  | |||||  |  |. :.||. |  |
     325 VSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEV 374
                  .         .         .         .         .
     398 HFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPT 447
          |.||.| :: :|.||.|.|. |||.||||.||||||| |||::| ||| 
     375 VFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPL 424
                  .         .         .         .         .
     448 EGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGREN..V 495
          | | .||.:|: :||..||  :|:|||||:||  .||||| ||  .  |
     425 AGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV 474
                  .         .         .         .         .
     496 TMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARAL 545
         . :|| :| |||| : ||  ||.|: | ||::| ||||||||||||||||
     475 SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARAL 524
                  .         .         .         .         .
     546 VRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNA 595
         || | |||||||||||||||| ||| ||||||.||| |||||||||:.||
     525 VRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 574
                  .         .         .         .         .
     596 DVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESK 645
         |.|  | .| : | | | :|: :||||| :|..| || . :         
     575 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ.AGTKRQ......... 614