Alignment of Gene 2 cDNA on Huamn MDR3 and MDR 1

CLUSTAL W(1.60) multiple sequence alignment



GENE2_FUGU      ATGGCCTTAAAGATCGATACGGCCGAAACAAACGGTGATCTGAGCCATGATTCCAAGGAC
MDR3_HUMAN      ------ATGGATCTTGAGGCGGCAAAGAACGGAACAGCCTGGCGCCCCACGAGCGCGGAG
MDR1_HUMAN      ----------------------ATGGATCTTGAAGGGGACCGCAATGGAGGAGCAAAGAA
                                                    *    *           *   ** 

GENE2_FUGU      GATGGTGCCAAGAATGAAAAGAAAAAGAAGAATAAAAAGGAAAAGCCACCACAGGAGCCC
MDR3_HUMAN      GGCGACTTTGAACTGGGCATCAGCAGCAAACAAAAAAGGAAAAAAACGAAGACAGTGAAA
MDR1_HUMAN      GAAGAACTT--TTTTAAACTGAACAATAAAAGTGAAAAAGATAAGAAGGAAAAGAAACCA
                *  *                 *  *  **     ***   * **                

GENE2_FUGU      ATGGTGGGCCCCATTACTCTGTTCCGATTTGCAGACCGCTGGGACGTCGTGCTGCTCATC
MDR3_HUMAN      ATGATTGGAGTATTAACATTGTTTCGATACTCCGATTGGCAGGATAAATTGTTTATGTCG
MDR1_HUMAN      ACTGTCAGTGTATTTTCAATGTTTCGCTATTCAAATTGGCTTGACAAGTTGTATATGGTG
                *   *  *     *  *  **** ** *   *  *  *    **     **    *    

GENE2_FUGU      AGCGGGACAGTGATGGCCATGGTCAACGGCACCGTGATGCCCCTCATGTGCATTGTCTTT
MDR3_HUMAN      CTGGGTACCATCATGGCCATAGCTCACGGATCAGGTCTCCCCCTCATGATGATAGTATTT
MDR1_HUMAN      GTGGGAACTTTGGCTGCCATCATCCATGGGGCTGGACTTCCTCTCATGATGCTGGTGTTT
                   ** **  *    *****     * **  * *   * ** ******    * ** ***

GENE2_FUGU      GGAGAAATGACGGACAGTTTTATATACGCTGA------------CATGGCCCAACACAAC
MDR3_HUMAN      GGAGAGATGACTGACAAATTTGTTGATACTG-------------CAGGAAACTTCTCCTT
MDR1_HUMAN      GGAGAAATGACAGATATCTTTGCAAATGCAGGAAATTTAGAAGATCTGATGTCAAACATC
                ***** ***** ** *  ***    *  * *                *        *   

GENE2_FUGU      GCAAGTGGCTGGAATTCTACTACTACTAT-TCTGAACAGCACGTTACAGGAGGACATGCA
MDR3_HUMAN      TCCAGTGAACTTTTCCTTGTCGCTGCTAAATCCAGGCAAAATTCTGGAAGAAGAAATGAC
MDR1_HUMAN      ACTAATAGAAGTGATATCAATGATACAGGGTTCTT-CATGAATCTGGAGGAAGACATGAC
                 * * *                 * *    *     **  *   *  * ** ** ***  

GENE2_FUGU      AAGATTCGCCATTTATTACTCCGTCTTGGGATTTGTTGTGCTGCTGGCCGCCTACATGCA
MDR3_HUMAN      TAGATATGCATATTACTACTCAGGATTGGGTGCTGGAGTTCTTGTTGCTGCCTATATACA
MDR1_HUMAN      CAGGTATGCCTATTATTACAGTGGAATTGGTGCTGGGGTGCTGGTTGCTGCTTACATTCA
                 ** *  **   *** ***   *   * **   **  ** **  * ** ** ** ** **

GENE2_FUGU      GGTGTCCTTCTGGACCATAACAGCCGGGCGCCAGGTGAAACGCATCCGCAGCTTGTTTTT
MDR3_HUMAN      AGTTTCATTTTGGACTTTGGCAGCTGGTCGACAGATCAGGAAAATTAGGCAGAAGTTTTT
MDR1_HUMAN      GGTTTCATTTTGGTGCCTGGCAGCTGGAAGACAAATACACAAAATTAGAAAACAGTTTTT
                 ** ** ** ***    *  **** **  * **  *       **  *      ******

GENE2_FUGU      CCACTGCATCATGCAGCAGGAGATCAGCTGGTTTGACGTGAACGACACAGGGGAGCTCAA
MDR3_HUMAN      TCATGCTATTCTACGACAGGAAATAGGATGGTTTGACATCAATGACACCACTGAACTCAA
MDR1_HUMAN      TCATGCTATAATGCGACAGGAGATAGGCTGGTTTGATGTGCACGATGTTGGGGAGCTTAA
                 **    **  * *  ***** **  * ********  *  * **       ** ** **

GENE2_FUGU      CACTCGACTGACGGACGACGTCTACAAGATCCAGGAGGGCATCGGTGACAAGGTGGGGCT
MDR3_HUMAN      TACGCGGCTAACAGATGACATCTCCAAAATCAGTGAAGGAATTGGTGACAAGGTTGGAAT
MDR1_HUMAN      CACCCGACTTACAGATGATGTCTCTAAGATTAATGAAGTTATTGGTGACAAAATTGGAAT
                 ** ** ** ** ** **  ***  ** **    ** *  ** ********  * **  *

GENE2_FUGU      GCTGATCCAGGCGTACACCACCTTCATCACGGCCTTCATCATCGGCTTCACCACGGGCTG
MDR3_HUMAN      GTTCTTTCAAGCAGTAGCCACGTTTTTTGCAGGATTCATAGTGGGATTCATCAGAGGATG
MDR1_HUMAN      GTTCTTTCAGTCAATGGCAACATTTTTCACTGGGTTTATAGTAGGATTTACACGTGGTTG
                * *  * **  *     * ** **  *  * *  ** **  * ** ** *     ** **

GENE2_FUGU      GAAACTGACGCTGGTCATCCTGGCCGTGAGCCCCGCGCTGGCCATTTCGGCCGCCTTCTT
MDR3_HUMAN      GAAGCTCACCCTTGTGATAATGGCCATCAGCCCTATTCTAGGACTCTCTGCAGCCGTTTG
MDR1_HUMAN      GAAGCTAACCCTTGTGATTTTGGCCATCAGTCCTGTTCTTGGACTGTCAGCTGCTGTCTG
                *** ** ** ** ** **  ***** * ** **    ** *   * ** ** **  * * 

GENE2_FUGU      CAGTAAAGTGCTTGCGTCCTTCACCAGTAAGGAGCAGACGGCGTACGCCAAAGCCGGAGC
MDR3_HUMAN      GGCAAAGATACTCTCGGCATTTAGTGACAAAGAACTAGCTGCTTATGCAAAAGCAGGCGC
MDR1_HUMAN      GGCAAAGATACTATCTTCATTTACTGATAAAGAACTCTTAGCGTATGCAAAAGCTGGAGC
                    **  * **  *  * ** *     ** ** *     ** ** ** ***** ** **

GENE2_FUGU      CGTGGCGGAGGAAGTGCTGTCCGCCATCAGGACCGTGTTCGCCTTCAGTGGTCAGACCAG
MDR3_HUMAN      CGTGGCAGAAGAGGCTCTGGGGGCCATCAGGACTGTGATAGCTTTCGGGGGCCAGAACAA
MDR1_HUMAN      AGTAGCTGAAGAGGTCTTGGCAGCAATTAGAACTGTGATTGCATTTGGAGGACAAAAGAA
                 ** ** ** ** *   **   ** ** ** ** *** * ** **  * ** ** *  * 

GENE2_FUGU      AGAGATTGAGAGATACCACAAGAACCTGCGGGACGCAAAGGACGTGGGAGTGAAGAAGGC
MDR3_HUMAN      AGAGCTGGAAAGGTATCAGAAACATTTAGAAAATGCCAAAGAGATTGGAATTAAAAAAGC
MDR1_HUMAN      AGAACTTGAAAGGTACAACAAAAATTTAGAAGAAGCTAAAAGAATTGGGATAAAGAAAGC
                ***  * ** ** **  * **  *  *     * ** **     * **  * ** ** **

GENE2_FUGU      CATCTCCTCCAACATCGCCATGGGCTTCACCTTCCTGATGATCTACCTGTCCTATGCTCT
MDR3_HUMAN      TATTTCAGCAAACATTTCCATGGGTATTGCCTTCCTGTTAATATATGCATCATATGCACT
MDR1_HUMAN      TATTACAGCCAATATTTCTATAGGTGCTGCTTTCCTGCTGATCTATGCATCTTATGCTCT
                 **  *  * ** **  * ** **     * ****** * ** **    ** ***** **

GENE2_FUGU      GGCCTTCTGGTACGGGAGTACGCTCATCCTGAATTTTGAGTACACCATCGGCAATTTACT
MDR3_HUMAN      GGCCTTCTGGTATGGATCCACTCTAGTCATATCAAAAGAATATACTATTGGAAATGCAAT
MDR1_HUMAN      GGCCTTCTGGTATGGGACCACCTTGGTCCTCTCAGGGGAATATTCTATTGGACAAGTACT
                ************ **    **  *  ** *       ** **  * ** **  *   * *

GENE2_FUGU      GACTGTGTTTTTTGTCGTGCTTATTGGAGCGTTCAGCGTCGGACAGACCTCTCCGAACAT
MDR3_HUMAN      GACAGTTTTTTTTTCAATCCTAATTGGAGCTTTCAGTGTTGGCCAGGCTGCCCCATGTAT
MDR1_HUMAN      CACTGTATTCTTTTCTGTATTAATTGGGGCTTTTAGTGTTGGACAGGCATCTCCAAGCAT
                 ** ** ** ***    *  * ***** ** ** ** ** ** *** *  * **    **

GENE2_FUGU      CCAGAATTTTGCCAGCGCCCGAGGAGCCGCCTATAAAGTGTACAGCATCATCGATAACAA
MDR3_HUMAN      TGATGCTTTTGCCAATGCAAGAGGAGCAGCATATGTGATCTTTGATATTATTGATAATAA
MDR1_HUMAN      TGAAGCATTTGCAAATGCAAGAGGAGCAGCTTATGAAATCTTCAAGATAATTGATAATAA
                  *    ***** *  **  ******* ** ***    * *     ** ** ***** **

GENE2_FUGU      GCCAAACATTGACAGCTTTTCAGAGGACGGTTTCAAGCCGGACTTCATCAAAGGTGACAT
MDR3_HUMAN      TCCTAAAATTGACAGTTTTTCAGAGAGAGGACACAAACCAGACAGCATCAAAGGGAATTT
MDR1_HUMAN      GCCAAGTATTGACAGCTATTCGAAGAGTGGGCACAAACCAGATAATATTAAGGGAAATTT
                 ** *  ******** * ***  **   **   *** ** **    ** ** **  *  *

GENE2_FUGU      CGAGTTCAAGAACATCCACTTCAATTACCCTTCGAGGCCTGAAGTCAAAATCTTGAACAA
MDR3_HUMAN      GGAGTTCAATGATGTTCACTTTTCTTACCCTTCTCGAGCTAACGTCAAGATCTTGAAGGG
MDR1_HUMAN      GGAATTCAGAAATGTTCACTTCAGTTACCCATCTCGAAAAGAAGTTAAGATCTTGAAGGG
                 ** ****   *  * *****   ****** **  *     * ** ** ********   

GENE2_FUGU      CATGTCTCTGAGCGTGAAGAGCGGACAGACCATTGCTTTGGTGGGGAGCAGCGGCTGTGG
MDR3_HUMAN      CCTCAACCTGAAGGTGCAGAGTGGGCAGACGGTGGCCCTGGTTGGAAGTAGTGGCTGTGG
MDR1_HUMAN      CCTGAACCTGAAGGTGCAGAGTGGGCAGACGGTGGCCCTGGTTGGAAACAGTGGCTGTGG
                * *    ****  *** **** ** *****  * **  **** ** *  ** ********

GENE2_FUGU      CAAAAGTACCACCATCCAGCTGCTGCAGAGGTTCTACGACCCCGAGGAAGGAGCTGTATT
MDR3_HUMAN      GAAGAGCACAACGGTCCAGCTGATACAGAGGCTCTATGACCCTGATGAGGGCACAATTAA
MDR1_HUMAN      GAAGAGCACAACAGTCCAGCTGATGCAGAGGCTCTATGACCCCACAGAGGGGATGGTCAG
                 ** ** ** **  ******** * ****** **** *****    ** **     *   

GENE2_FUGU      TATCGACGGTCACGACATCCGCTCCCTCAACATCCGCTACCTGAGAGAGATGATCGGAGT
MDR3_HUMAN      CATTGATGGGCAGGATATTAGGAACTTTAATGTAAACTATCTGAGGGAAATCATTGGTGT
MDR1_HUMAN      TGTTGATGGACAGGATATTAGGACCATAAATGTAAGGTTTCTACGGGAAATCATTGGTGT
                  * ** ** ** ** **  *   * * **  *    *  **  * ** ** ** ** **

GENE2_FUGU      GGTCAGCCAGGAGCCCGTTCTTTTCGCCACCACCATCACCGAGAACATCAGATACGGCCG
MDR3_HUMAN      GGTGAGTCAGGAGCCGGTGCTGTTTTCCACCACAATTGCTGAAAATATTTGTTATGGCCG
MDR1_HUMAN      GGTGAGTCAGGAACCTGTATTGTTTGCCACCACGATAGCTGAAAACATTCGCTATGGCCG
                *** ** ***** ** **  * **  ******* **  * ** ** **  * ** *****

GENE2_FUGU      ACTGGACGTGACGCAAGAGGAGATCGAACGAGCCACTAAAGAGTCCAACGCTTATGACTT
MDR3_HUMAN      TGGAAATGTAACCATGGATGAGATAAAGAAAGCTGTCAAAGAGGCCAACGCCTATGAGTT
MDR1_HUMAN      TGAAAATGTCACCATGGATGAGATTGAGAAAGCTGTCAAGGAAGCCAATGCCTATGACTT
                     * ** **    ** *****  *   ***    ** **  **** ** ***** **

GENE2_FUGU      CATCATGAACCTTCCACAGAAGTTTGAGACGCTGGTGGGAGATCGAGGGACTCAGCTGAG
MDR3_HUMAN      TATCATGAAATTACCACAGAAATTTGACACCCTGGTTGGAGAGAGAGGGGCCCAGCTGAG
MDR1_HUMAN      TATCATGAAACTGCCTCATAAATTTGACACCCTGGTTGGAGAGAGAGGGGCCCAGTTGAG
                 ********  * ** ** ** ***** ** ***** *****  ***** * *** ****

GENE2_FUGU      CGGAGGACAGAAGCAGAGGATCGCCATCGCTCGAGCTCTGGTCCGCAACCCTAAAATCCT
MDR3_HUMAN      TGGTGGGCAGAAGCAGAGGATCGCCATTGCACGTGCCCTGGTTCGCAACCCCAAGATCCT
MDR1_HUMAN      TGGTGGGCAGAAGCAGAGGATCGCCATTGCACGTGCCCTGGTTCGCAACCCCAAGATCCT
                 ** ** ******************** ** ** ** ***** ******** ** *****

GENE2_FUGU      CCTGCTGGACGAGGCCACGTCTGCCCTCGATGCTGAGAGCGAGACCATCGTACAGGCTGC
MDR3_HUMAN      TCTGCTGGATGAGGCCACGTCAGCATTGGACACAGAAAGTGAAGCTGAGGTACAGGCAGC
MDR1_HUMAN      CCTGCTGGATGAGGCCACGTCAGCCTTGGACACAGAAAGCGAAGCAGTGGTTCAGGTGGC
                 ******** *********** **  * **  * ** ** **  *    ** ****  **

GENE2_FUGU      TCTGGACAAGGTCCGACTGGGTCGCACCACCATCGTGGTCGCTCACCGACTCTCGACCAT
MDR3_HUMAN      TCTGGATAAGGCCAGAGAAGGCCGGACCACCATTGTGATAGCACACCGACTGTCTACGGT
MDR1_HUMAN      TCTGGATAAGGCCAGAAAAGGTCGGACCACCATTGTGATAGCTCATCGTTTGTCTACAGT
                ****** **** * **   ** ** ******** *** * ** ** **  * ** **  *

GENE2_FUGU      CAGAAACGCCGACATCATTGCTGGATTCAGTAATGGCAAAATCGTGGAGCAGGGGACTCA
MDR3_HUMAN      CCGAAATGCAGATGTCATCGCTGGGTTTGAGGATGGAGTAATTGTGGAGCAAGGAAGCCA
MDR1_HUMAN      TCGTAATGCTGACGTCATCGCTGGTTTCGATGATGGAGTCATTGTGGAGAAAGGAAATCA
                  * ** ** **  **** ***** **     ****    ** ****** * ** *  **

GENE2_FUGU      CAGCCAGCTGATGGAGATAAAGGGAGTCTATCATGGCCTGGTGACCATGCAGACGTT---
MDR3_HUMAN      CAGCGAACTGATGAAGAAGGAAGGGGTGTACTTCAAACTTGTCAACATGCAGACATCAGG
MDR1_HUMAN      TGATGAACTCATGAAAGAGAAAGGCATTTACTTCAAACTTGTCACAATGCAGACAGCAGG
                     * ** *** *     * **  * **       ** ** *  ********      

GENE2_FUGU      ---CCACAATGTGGAGGAGGAAA------AT-ACCGCCATGTCGGAGTTATCTGCTGGGG
MDR3_HUMAN      AAGCCAGATCCAGTCAGAAGAAT------TTGAACTAAATGATGAAAAGGCTGCCACTAG
MDR1_HUMAN      AAATGAAGTTGAATTAGAAAATGCAGCTGATGAATCCAAAAGTGAAATTGATGCCTTGGA
                     *          **  *         * *     *    * *        *     

GENE2_FUGU      AGAAGAGCCCTGTGGAAAAGACCGTCTCCCAGTCGTCCATCATCAGGAGGAAGTCCACCA
MDR3_HUMAN      AATGGCCCCAAATGGCTGGAAATCTCGCCTATTTAGGCATTCTACTCAGAAAAACCTTAA
MDR1_HUMAN      AATGTCTTCAAATGATTCAAGATCCAGTCTAATAAGAAA--A----AGATCAACTCGTAG
                *       *   **              * * *     *            *   *    

GENE2_FUGU      GAGGGTCCTCGTTTGCCGCGTCAGAAGGAACCAAA-GAGGAA-AAGACAGAAGAGGATGA
MDR3_HUMAN      AAA--TTCACAAATG---TGTCAGAAGAGCCTTGATGTGGAA-ACCGATGGACTTGAAGC
MDR1_HUMAN      GAGTGTCCGTGGATCACAAGCCCAAGACAGAAAGCTTAGTACCAAAGAGGCTCTGGATGA
                 *   * *     *     * *  *             * *  *     *     ** * 

GENE2_FUGU      AGACGTTCCCGACGTGTCGTTCTTTAAAGTGCTGCATCTGAACATCCCCGAGTGGCCCTA
MDR3_HUMAN      AAATGTGCCACCAGTGTCCTTTCTGAAGGTCCTGAAACTGAATAAAACAGAATGGCCCTA
MDR1_HUMAN      AAGTATACCTCCAGTTTCCTTTTGGAGGATTATGAAGCTAAATTTAACTGAATGGCCTTA
                *    * **    ** ** **    *   *  ** * ** **     * ** ***** **

GENE2_FUGU      CATCCTTGTGGGGCTCATCTGCGCTACGATCAATGGAGCCATGCAGCCGGTCTTCGCCAT
MDR3_HUMAN      CTTTGTCGTGGGAACAGTATGTGCCATTGCCAATGGGGGGCTTCAGCCGGCATTTTCAGT
MDR1_HUMAN      TTTTGTTGTTGGTGTATTTTGTGCCATTATAAATGGAGGCCTGCAACCAGCATTTGCAAT
                  *  * ** **     * ** ** *     ***** *   * ** ** *  **  *  *

GENE2_FUGU      CCTCTTCTCCAAGATCATCACTGTGTTTGCGGATCCAGACCGTGATTCTGTCAGGAGGAA
MDR3_HUMAN      CATATTCTCAGAGATCATAGCGATTTTTGGA---CCAGGCGATGATGCAGTGAAGCAGCA
MDR1_HUMAN      AATATTTTCAAAGATTATAGGGGTTTTTACAAGAATTGATGATCCTGAAACAAAACGACA
                  * ** **  **** **     * ***         *    *  *      *      *

GENE2_FUGU      GA---GTGAATTCATTTCTCTGATGTTTGTCGTTATTGGCTGTGTGTCATTTGTCACCAT
MDR3_HUMAN      GAAGTGCAACATATTCTCTTTGATTTTCTTATTTCTGGGAATTATTTCTTTTTTTACTTT
MDR1_HUMAN      GAATAGTAACTTGTTTTCACTATTGTTTCTAGCCCTTGGAATTATTTCTTTTATTACATT
                **   *  *  *  * **  *  * **  *     * **   * * ** *** * **  *

GENE2_FUGU      GTTTTTACAGGGTTACTGTTTCGGTAAATCCGGAGAGATTCTGACGCTGAAGCTGAGACT
MDR3_HUMAN      CTTCCTTCAGGGTTTCACGTTTGGGAAAGCTGGCGAGATCCTCACCAGAAGACTGCGGTC
MDR1_HUMAN      TTTCCTTCAGGGTTTCACATTTGGCAAAGCTGGAGAGATCCTCACCAAGCGGCTCCGATA
                 **  * ******* *   ** ** *** * ** ***** ** **       **  *   

GENE2_FUGU      CCGGGCGTTCACGGCGATGATGAGACAGGACCTCAGCTGGTACGACAATCCCCAAAACAC
MDR3_HUMAN      AATGGCTTTTAAAGCAATGCTAAGACAGGACATGAGCTGGTTTGATGACCATAAAAACAG
MDR1_HUMAN      CATGGTTTTCCGATCCATGCTCAGACAGGATGTGAGTTGGTTTGATGACCCTAAAAACAC
                   **  **     * *** * ********  * ** ****  **  * *   ****** 

GENE2_FUGU      CGTTGGCGCTCTCACCACTAGGCTGGCTGCCGACGCCGCCCAAGTACAAGGAGCTGCAGG
MDR3_HUMAN      TACTGGTGCACTTTCTACAAGACTTGCCACAGATGCTGCCCAAGTCCAAGGAGCCACAGG
MDR1_HUMAN      CACTGGAGCATTGACTACCAGGCTCGCCAATGATGCTGCTCAAGTTAAAGGGGCTATAGG
                   *** **  *  * ** ** ** **    ** ** ** *****  **** **   ***

GENE2_FUGU      GGTGCGCCTGGCGACAATAATGCAGAACTTCGCCAACCTGGGCACCAGCATCATCATCGC
MDR3_HUMAN      AACCAGGTTGGCTTTAATTGCACAGAATATAGCTAACCTTGGAACTGGTATTATCATATC
MDR1_HUMAN      TTCCAGGCTTGCTGTAATTACCCAGAATATAGCAAATCTTGGGACAGGAATAATTATATC
                     *  * **   ***    *****  * ** ** ** ** **  * ** ** **  *

GENE2_FUGU      CTTTGTTTACGGCTGGGAGCTGACCCTGCTCATCCTGGCCGTGGTGCCCCTCATCGCGGC
MDR3_HUMAN      ATTTATCTACGGTTGGCAGTTAACCCTATTGCTATTAGCAGTTGTTCCAATTATTGCTGT
MDR1_HUMAN      CTTCATCTATGGTTGGCAACTAACACTGTTACTCTTAGCAATTGTACCCATCATTGCAAT
                 **  * ** ** *** *  * ** **  *  *  * **  * ** **  * ** **   

GENE2_FUGU      CGCCGGAGCCGCTGAGATCAAGCTGCTCGCGGGTCACGCCGCCAAAGACAAGAAGGAGCT
MDR3_HUMAN      GTCAGGAATTGTTGAAATGAAATTGTTGGCTGGAAATGCCAAAAGAGATAAAAAAGAACT
MDR1_HUMAN      AGCAGGAGTTGTTGAAATGAAAATGTTGTCTGGACAAGCACTGAAAGATAAGAAAGAACT
                  * ***   * *** ** **  ** *  * **  * **    * *** ** ** ** **

GENE2_FUGU      GGAGAAGGCCGGAAAGATCGCCACAGAGGCCATCGAGAACGTCAGAACCGTCGTGTCCCT
MDR3_HUMAN      GGAAGCTGCTGGAAAGATTGCAACAGAGGCAATAGAAAATATTAGGACAGTTGTGTCTTT
MDR1_HUMAN      AGAAGGTGCTGGGAAGATCGCTACTGAAGCAATAGAAAACTTCCGAACCGTTGTTTCTTT
                 **    ** ** ***** ** ** ** ** ** ** **  *  * ** ** ** **  *

GENE2_FUGU      CAGCAGAGAACCAAAATTTGAGTGTTTATATGAGGAGAATCTCAGAGTGCCGTACAAGAA
MDR3_HUMAN      GACCCAGGAAAGAAAATTTGAATCAATGTATGTTGAAAAATTGTATGGACCTTACAGGAA
MDR1_HUMAN      GACTCAGGAGCAGAAGTTTGAACATATGTATGCTCAGAGTTTGCAGGTACCATACAGAAA
                 *     **    ** *****     * ****   * *   *    *  ** ****  **

GENE2_FUGU      CTCCCAGAAAAAGGCCCACGTGTACGGCTTAACCTACTCCTTCTCCCAGGCCATGATCTA
MDR3_HUMAN      TTCTGTGCAGAAGGCACACATCTATGGAATTACTTTTAGTATCTCACAAGCATTTATGTA
MDR1_HUMAN      CTCTTTGAGGAAAGCACACATCTTTGGAATTACATTTTCCTTCACCCAGGCAATGATGTA
                 **   *   ** ** *** * *  **  * ** *      ** * ** **  * ** **

GENE2_FUGU      CTTTGCTTACGCTGCCTGTTTCCGCTTCGGAGCCTGGCTGATTGAAGCAGGACGGATGGA
MDR3_HUMAN      TTTTTCCTATGCCGGTTGTTTTCGATTTGGTGCATATCTCATTGTGAATGGACATATGCG
MDR1_HUMAN      TTTTTCCTATGCTGGATGTTTCCGGTTTGGAGCCTACTTGGTGGCACATAAACTCATGAG
                 *** * ** ** *  ***** ** ** ** ** *   *  * *       **  ***  

GENE2_FUGU      CGTGGAGGGAGTGTTCCTGGTGGTTTCTGCGGTGCTGTACGGCGCCATGGCCGTGGGGGA
MDR3_HUMAN      CTTCAGAGATGTTATTCTGGTGTTTTCTGCAATTGTATTTGGTGCAGTGGCTCTAGGACA
MDR1_HUMAN      CTTTGAGGATGTTCTGTTAGTATTTTCAGCTGTTGTCTTTGGTGCCATGGCCGTGGGGCA
                * *    *  **  *  * **  **** **  *  * *  ** **  ****  * **  *

GENE2_FUGU      AGCTAACACCTTTGCTCCGAACTACGCCAAGGCCAAAATGGCTGCTTCCTACCTGATGAT
MDR3_HUMAN      TGCCAGTTCATTTGCTCCAGACTATGCTAAAGCTAAGCTGTCTGCAGCCCACTTATTCAT
MDR1_HUMAN      AGTCAGTTCATTTGCTCCTGACTATGCCAAAGCCAAAATATCAGCAGCCCACATCATCAT
                 *  *   * ********  **** ** ** ** **  *  * **  ** ** *  * **

GENE2_FUGU      GCTAATAAACAAGAAGCCCGCCATTGATAACCTCTCAGAGGAGGGGACGTCTCCGGAAAA
MDR3_HUMAN      GCTGTTTGAAAGACAACCTCTGATTGACAGCTACAGTGAAGAGGGGCTGAAGCCTGATAA
MDR1_HUMAN      GATCATTGAAAAAACCCCTTTGATTGACAGCTACAGCACGGAAGGCCTAATGCCGAACAC
                * *  *  * *     **    ***** * *  *      ** **       **  * * 

GENE2_FUGU      ATACGACGGTAATGTGCATTTCGAGGGTGTTAAATTCAACTACCCGTCGCGGCCCGATGT
MDR3_HUMAN      ATTTGAAGGAAATATAACATTTAATGAAGTCGTGTTCAACTATCCCACCCGAGCAAACGT
MDR1_HUMAN      ATTGGAAGGAAATGTCACATTTGGTGAAGTTGTATTCAACTATCCCACCCGACCGGACAT
                **  ** ** *** *    **    *  **    ******** **  * **  *  *  *

GENE2_FUGU      GACCATACTCCAGGGGCTGAACCTGAAGGTGAAAAAGGGAGAAACTCTGGCCTTGGTGGG
MDR3_HUMAN      GCCAGTGCTTCAGGGGCTGAGCCTGGAGGTGAAGAAAGGCCAGACACTAGCCCTGGTGGG
MDR1_HUMAN      CCCAGTGCTTCAGGGACTGAGCCTGGAGGTGAAGAAGGGCCAGACGCTGGCTCTGGTGGG
                  *  * ** ***** **** **** ******* ** **  * ** ** **  *******

GENE2_FUGU      CAGCAGCGGTTGTGGAAAGAGCACCACCATCCAGCTGCTGGAGAGGTTTTATGACCCCAG
MDR3_HUMAN      CAGCAGTGGCTGTGGGAAGAGCACGGTGGTCCAGCTCCTGGAGCGGTTCTACGACCCCTT
MDR1_HUMAN      CAGCAGTGGCTGTGGGAAGAGCACAGTGGTCCAGCTCCTGGAGCGGTTCTACGACCCCTT
                ****** ** ***** ********     ******* ****** **** ** ******  

GENE2_FUGU      AGAGGGGAGAGTGTCACTGGACGGTGTCAACGTGAAACAGCTGAACATTCACTGGCTGAG
MDR3_HUMAN      GGCGGGGACAGTGCTTCTCGATGGTCAAGAAGCAAAGAAACTCAATGTCCAGTGGCTCAG
MDR1_HUMAN      GGCAGGGAAAGTGCTGCTTGATGGCAAAGAAATAAAGCGACTGAATGTTCAGTGGCTCCG
                 *  **** ****   ** ** **     *    **    ** **  * ** *****  *

GENE2_FUGU      GTCTCAGATCGGCATCGTCTCCCAGGAGCCGGTGCTGTTCGACTGCTCCCTGGCTGAGAA
MDR3_HUMAN      AGCTCAACTCGGAATCGTGTCTCAGGAGCCTATCCTATTTGACTGCAGCATTGCCGAGAA
MDR1_HUMAN      AGCACACCTGGGCATCGTGTCCCAGGAGCCCATCCTGTTTGACTGCAGCATTGCTGAGAA
                  * **  * ** ***** ** ********  * ** ** ******  * * ** *****

GENE2_FUGU      CATCGCCTACGGAGACAACAGTCGCTCCGTGTCCATGGATGAGATACT---TGCTGCTAA
MDR3_HUMAN      TATTGCCTATGGAGACAACAGCCGGGTTGTATCACAGGATGAAATTGTGAGTGCAGCCAA
MDR1_HUMAN      CATTGCCTATGGAGACAACAGCCGGGTGGTGTCACAGGAAGAGATCGTGAGGGCAGCAAA
                 ** ***** *********** **    ** **   *** ** **  *    ** ** **

GENE2_FUGU      AGCAGCCAACATCCACAGCTTCATCGAAGGGCTGCCTCAGAGATACGACACTCAGGCTGG
MDR3_HUMAN      AGCTGCCAACATACATCCTTTCATCGAGACGTTACCCCACAAATATGAAACAAGAGTGGG
MDR1_HUMAN      GGAGGCCAACATACATGCCTTCATCGAGTCACTGCCTAATAAATATAGCACTAAAGTAGG
                 *  ******** **    ********     * **  * * ***    **    *  **

GENE2_FUGU      TGATAAGGGAACACAGCTGTCAGGGGGCCAGAAGCAGCGTGTCGCCATAGCCCGAGCCAT
MDR3_HUMAN      AGATAAGGGGACTCAGCTCTCAGGAGGTCAAAAACAGAGGATTGCTATTGCCCGAGCCCT
MDR1_HUMAN      AGACAAAGGAACTCAGCTCTCTGGTGGCCAGAAACAACGCATTGCCATAGCTCGTGCCCT
                 ** ** ** ** ***** ** ** ** ** ** **  *  * ** ** ** ** *** *

GENE2_FUGU      CATCCGCAACCCCAAACTGTTGCTCCTGGACGAGGCCACGTCTGCGCTCGACACTGAGAG
MDR3_HUMAN      CATCAGACAACCTCAAATCCTCCTGTTGGATGAAGCTACATCAGCTCTGGATACTGAAAG
MDR1_HUMAN      TGTTAGACAGCCTCATATTTTGCTTTTGGATGAAGCCACGTCAGCTCTGGATACAGAAAG
                  *  *  * **  *  *  * **  **** ** ** ** ** ** ** ** ** ** **

GENE2_FUGU      TGAGAAGGTGGTGCAGGAGGCGTTGGACCAGGCCAGGAAGGGCAGGACGTGCATCGTGGT
MDR3_HUMAN      TGAAAAGGTTGTCCAAGAAGCCCTGGACAAAGCCAGAGAAGGCCGCACCTGCATTGTGAT
MDR1_HUMAN      TGAAAAGGTTGTCCAAGAAGCCCTGGACAAAGCCAGAGAAGGCCGCACCTGCATTGTGAT
                *** ***** ** ** ** **  ***** * *****  * *** * ** ***** *** *

GENE2_FUGU      AGCCCACCGTCTGTCCACCATCCAGAACGCCGACTGCATCGCTGTGTTCCAGGGAGGAGT
MDR3_HUMAN      TGCTCACCGCCTGTCCACCATCCAGAATGCAGACTTAATAGTGGTGTTTCAGAATGGGAG
MDR1_HUMAN      TGCTCACCGCCTGTCCACCATCCAGAATGCAGACTTAATAGTGGTGTTTCAGAATGGCAG
                 ** ***** ***************** ** ****  ** *  ***** ***   **   

GENE2_FUGU      GGTGGTGGAAAAGGGGACGCACCAGCAGCTGATCGCCAAGAAGGGAGTGTACCACATGCT
MDR3_HUMAN      AGTCAAGGAGCATGGCACGCATCAGCAGCTGCTGGCACAGAAAGGCATCTATTTTTCAAT
MDR1_HUMAN      AGTCAAGGAGCATGGCACGCATCAGCAGCTGCTGGCACAGAAAGGCATCTATTTTTCAAT
                 **   ***  * ** ***** ********* * **  **** **  * **        *

GENE2_FUGU      GGTCACCAAACAGATGGGCTATCACAACGACTGA
MDR3_HUMAN      GGTCAGTGTCCAGGCTGGGACACAGAACTTATGA
MDR1_HUMAN      GGTCAGTGTCCAGGCTGGAACAAAGCGCCAGTGA
                *****     ***   **     *   *   ***