Gene 2

CLUSTAL W(1.60) multiple sequence alignment



GENE2_FUGU      MALKIDTAETNGDLSHDSKDDGAKNEKK-KKNKKEKPPQEPMVGPITLFRFADRWDVVLL
MDR1_HUMAN      MDLEGD---RNGGAKK--KNFFKLNNKS-EKDKKEK---KPTVSVFSMFRYSNWLDKLYM
MDR3_HUMAN      MDLEAA---KNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFM
                * *       **   .              * *. *      .   ..**..   * . .

GENE2_FUGU      ISGTVMAMVNGTVMPLMCIVFGEMTDSFIYADMAQHNASGWNSTTTILNS----TLQEDM
MDR1_HUMAN      VVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDM
MDR3_HUMAN      SLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFS--LSLLNPG--KILEEEM
                  **. *. .*. .*** .******* *  .        .      .        *.*.*

GENE2_FUGU      QRFAIYYSVLGFVVLLAAYMQVSFWTITAGRQVKRIRSLFFHCIMQQEISWFDVNDTGEL
MDR1_HUMAN      TRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGEL
MDR3_HUMAN      TRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTEL
                 *.* *** .*  **.***.*****...****...**  ***.*..*** ***..*  **

GENE2_FUGU      NTRLTDDVYKIQEGIGDKVGLLIQAYTTFITAFIIGFTTGWKLTLVILAVSPALAISAAF
MDR1_HUMAN      NTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAV
MDR3_HUMAN      NTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAV
                *******. ** ******.*.  *. .** . **.**  ********.*.** * .*** 

GENE2_FUGU      FSKVLASFTSKEQTAYAKAGAVAEEVLSAIRTVFAFSGQTREIERYHKNLRDAKDVGVKK
MDR1_HUMAN      WAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKK
MDR3_HUMAN      WAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKK
                 .*.*..*. **  *********** * ***** ** ** .*.*** *.*  ** .*.**

GENE2_FUGU      AISSNIAMGFTFLMIYLSYALAFWYGSTLILNFEYTIGNLLTVFFVVLIGAFSVGQTSPN
MDR1_HUMAN      AITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPS
MDR3_HUMAN      AISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPC
                **..**..* .**.** *********.**..  **.**. .**** .*********..* 

GENE2_FUGU      IQNFASARGAAYKVYSIIDNKPNIDSFSEDGFKPDFIKGDIEFKNIHFNYPSRPEVKILN
MDR1_HUMAN      IEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILK
MDR3_HUMAN      IDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILK
                *  ** ****** .. **** * ***.*  * *** *** .**  .** ****  **** 

GENE2_FUGU      NMSLSVKSGQTIALVGSSGCGKSTTIQLLQRFYDPEEGAVFIDGHDIRSLNIRYLREMIG
MDR1_HUMAN      GLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIG
MDR3_HUMAN      GLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIG
                .. * *.****.**** ********.**.** *** ** . .**.***  *. .***.**

GENE2_FUGU      VVSQEPVLFATTITENIRYGRLDVTQEEIERATKESNAYDFIMNLPQKFETLVGDRGTQL
MDR1_HUMAN      VVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQL
MDR3_HUMAN      VVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQL
                *********.***.*** ***  ** .** .* **.***.*** **.**.****.**.**

GENE2_FUGU      SGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRTTIVVAHRLST
MDR1_HUMAN      SGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLST
MDR3_HUMAN      SGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLST
                *******************************.***. ** **** * ******.******

GENE2_FUGU      IRNADIIAGFSNGKIVEQGTHSQLMEIKGVYHGLVTMQTFHN-VEEENTAMSELSAGEKS
MDR1_HUMAN      VRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDAL
MDR3_HUMAN      VRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELND--EKAAT
                .****.****  * ***.* * .**   *.*  **.***    .. *             

GENE2_FUGU      PVEKTVSQSSIIRRKSTRGSSFAASEGTKEEKTEE---DEDVPDVSFFKVLHLNIPEWPY
MDR1_HUMAN      EMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEA-LDESIPPVSFWRIMKLNLTEWPY
MDR3_HUMAN      RMAPNGWKSRLFR-HSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPY
                 .  .  .* . * .**.     .    .         .  .* *** ....**  ****

GENE2_FUGU      ILVGLICATINGAMQPVFAILFSKIITVFADPDR-DSVRRKSEFISLMFVVIGCVSFVTM
MDR1_HUMAN      FVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITF
MDR3_HUMAN      FVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDD-AVKQQKCNIFSLIFLFLGIISFFTF
                 .**  **  ** .** *...** ** .*   *     .. .   **.*. .* .** * 

GENE2_FUGU      FLQGYCFGKSGEILTLKLRLRAFTAMMRQDLSWYDNPQNTVGALTTRLAADAAQVQGAAG
MDR1_HUMAN      FLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIG
MDR3_HUMAN      FLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATG
                ****..***.***** .**   * .*.***.**.*  .*. ***.**** *****.** *

GENE2_FUGU      VRLATIMQNFANLGTSIIIAFVYGWELTLLILAVVPLIAAAGAAEIKLLAGHAAKDKKEL
MDR1_HUMAN      SRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKEL
MDR3_HUMAN      TRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKEL
                 *** * ** ***** ***.*.***.****.**.**.** .*  *.*.*.* * .*****

GENE2_FUGU      EKAGKIATEAIENVRTVVSLSREPKFECLYEENLRVPYKNSQKKAHVYGLTYSFSQAMIY
MDR1_HUMAN      EGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMY
MDR3_HUMAN      EAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMY
                * *********** ******..* *** .* . *  **.** .***..*.*.* .** .*

GENE2_FUGU      FAYAACFRFGAWLIEAGRMDVEGVFLVVSAVLYGAMAVGEANTFAPNYAKAKMAASYLMM
MDR1_HUMAN      FSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIM
MDR3_HUMAN      FSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFM
                *.** ****** *.    *    * ** **...**.*.*   .*** *****..*. . *

GENE2_FUGU      LINKKPAIDNLSEEGTSPEKYDGNVHFEGVKFNYPSRPDVTILQGLNLKVKKGETLALVG
MDR1_HUMAN      IIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVG
MDR3_HUMAN      LFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVG
                .  . * **  * **  *   .**. *  * ****.*  . .**** * ****.******

GENE2_FUGU      SSGCGKSTTIQLLERFYDPREGRVSLDGVNVKQLNIHWLRSQIGIVSQEPVLFDCSLAEN
MDR1_HUMAN      SSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAEN
MDR3_HUMAN      SSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAEN
                ******** .*********  * * ***   *.**..***...*******.*****.***

GENE2_FUGU      IAYGDNSRSVSMDEIRLAAKAANIHSFIEGLPQVYDTQAGDKGTQLSGGQKQRVAIARAI
MDR1_HUMAN      IAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARAL
MDR3_HUMAN      IAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARAL
                ******** ** .**  *** **** *** **  * *. **************.*****.

GENE2_FUGU      IRNPKLLLLDEATSALDTESEKVVQEALDQARKGRTCIVVAHRLSTIQNADCIAVFQGGV
MDR1_HUMAN      VRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGR
MDR3_HUMAN      IRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGR
                .*.*..***********************.** ******.*********** * ***.* 

GENE2_FUGU      VVEKGTHQQLIAKKGVYHMLVTKQMGYHND
MDR1_HUMAN      VKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
MDR3_HUMAN      VKEHGTHQQLLAQKGIYFSMVSVQAGTQNL
                * *.******.*.**.*  .*. * * .