Align-AA3

CLUSTAL W(1.60) multiple sequence alignment


MDR1_FUGU_      ------------------------------------------------------------
MSR3_FUGU_      ----------------MALKIDTAETNGDLSHDSKDDGAKNEKK--KKNKKEKPPQEPMV
MDR1_HUMAN      ------------------MDLEGDRNGG-----AKKKNFFKLN---NKSEKDKKEKKPTV
MDR1_LEIEN      -----MSRAHAAYANEGWSAPEGGIAGKDGSTRDCSGYGSQGPLFSAEEEVKGTVVRETV
MDR1_MOUSE      ------------------MEFEENLKG------RADKNFSKMG---KKSKKEKKEKKPAV
MDR1_RAT_       ------------------MEFEEGLNG------RADKNFSKMG---KKSKKEK-EKKPAV
MDR1_CRIGR      ------------------MEFEEDFSG------RKDKNFLKMG---RKSKKEKKEKKPVV
MDR1_CAEEL      MLRNGSLRQSLRTLDSFSLAPEDVLKTAIKTVEDYEGDNIDSNGEIKITRDAKEEVVNKV
MDR3_HUMAN      ------------------MDLEAAKNGTAWRPTSAEGDFELGIS--SKQKRKKTKTVKMI
MDR3_MOUSE      ------------------MELEEDLKG------RADKNFSKMG---KKSKKEKKEKKPAV
MDR3_CRIGR      ------------------MDLEAARNGTARRPGTVEGDFELGSI--SNQGRNKKKKVNLI
MDR3_CAEEL      --------------------MKKTKVN--------PEDDITLG---KFTPKPSPQDSYQG
                                                                            

MDR1_FUGU_      ----------------------MAIVNGLVNPLMCIVFGEMTDSFIQ-----EAKLSQNH
MSR3_FUGU_      GPITLFRFADRWDVVLLISGTVMAMVNGTVMPLMCIVFGEMTDSFIY-----ADMAQHNA
MDR1_HUMAN      SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFA--NAGNLEDLMSNI
MDR1_LEIEN      GPIEIFRYADATDRVLMIAGTAFAVACGAGMPVFSFIFGRIAMDLMS--------GVGS-
MDR1_MOUSE      GVFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFT-KAEASILPSITN-
MDR1_RAT_       GIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTPSRDPHSDRAITN-
MDR1_CRIGR      SVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFA--SVGNIPTNATNN
MDR1_CAEEL      SIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFIN------EQIVINN
MDR3_HUMAN      GVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVD--------TAGNF
MDR3_MOUSE      SVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFA--SVGNVSKNSTN-
MDR3_CRIGR      GPLTLFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMIVFGEMTDKFVN--------NAGNF
MDR3_CAEEL      NFFDVFRDADYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALME--------GESQ-
                                       .   *   *    .   ..                  

MDR1_FUGU_      ------NTSNPRANSTLEADMQRFSIYYSILGFAVLVVAYLQMSLWTLTAARQAKRIREL
MSR3_FUGU_      S---GWNSTTTILNSTLQEDMQRFAIYYSVLGFVVLLAAYMQVSFWTITAGRQVKRIRSL
MDR1_HUMAN      TNRSDINDTGFFMN--LEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQ
MDR1_LEIEN      ----------------AEEKAAKTSLIMVYVGIAMLIACAGHVMCWTVAACRQVARIRLL
MDR1_MOUSE      --QSGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQK
MDR1_RAT_       --QSEINSTHTVSDTSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQK
MDR1_CRIGR      --ATQVNASDIFGK--LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQK
MDR1_CAEEL      NGSTFLPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQIIVTCYLYVAEQMNNRLRRE
MDR3_HUMAN      SFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQK
MDR3_MOUSE      --MSEADKRAMFAK--LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQK
MDR3_CRIGR      SLPVNFSLSMINPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQN
MDR3_CAEEL      -----YQNGTINMP-WFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKK
                                              .   .              . .    .*  

MDR1_FUGU_      FFHGIMQQDISWYDVTETGELNTRLTEDVYKIQEGIGDKAGLLIQAASTFITSFVIGFVH
MSR3_FUGU_      FFHCIMQQEISWFDVNDTGELNTRLTDDVYKIQEGIGDKVGLLIQAYTTFITAFIIGFTT
MDR1_HUMAN      FFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTR
MDR1_LEIEN      FFRAVLRQDIGWHDEHSPGALTARMTGDTRVIQNGINDKLSQGIMNGSMGVIGYIAGFVF
MDR1_MOUSE      FFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFIS
MDR1_RAT_       FFHAIMNQEIGWFDVNDAGELNTRLTDDVSKINDGIGDKLGMFFQSITTFSAGFIIGFIS
MDR1_CRIGR      FFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTR
MDR1_CAEEL      FVKSILRQEISWFDTNHSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFTH
MDR3_HUMAN      FFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIR
MDR3_MOUSE      FFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTR
MDR3_CRIGR      FFHAILRQEMGWFDIKGTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIR
MDR3_CAEEL      YLKSVLRQDAKWFDETTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYM
                . . .. *.  * *      *  ..      .  * .**        .         *  

MDR1_FUGU_      GWKLTLVILAISPVLGLSAALYSKLLTSFTSKEQTAYAKAGAVAAEVLSSIRTVFAFSGQ
MSR3_FUGU_      GWKLTLVILAVSPALAISAAFFSKVLASFTSKEQTAYAKAGAVAEEVLSAIRTVFAFSGQ
MDR1_HUMAN      GWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQ
MDR1_LEIEN      SWELTLMMIGMMPFIIVMAAIIGSIVSKITESSRKYFAKAGSLATEVMENIRTVQAFGRE
MDR1_MOUSE      GWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQ
MDR1_RAT_       GWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQ
MDR1_CRIGR      GWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAAIRTVIAFGGQ
MDR1_CAEEL      SWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNGL
MDR3_HUMAN      GWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQ
MDR3_MOUSE      GWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQ
MDR3_CRIGR      GWKLTLVIMAISPILGLSAAVWAKILSTFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQ
MDR3_CAEEL      CWQLTLVMMITVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQ
                 * ***...   *            .   .      .. ** .  * .  **** .    

MDR1_FUGU_      RKAIKRYHKNLEDARDMGIKKGVAANTATGFSFLMIYLSYALAFWYGTTLVLNKEYTIGN
MSR3_FUGU_      TREIERYHKNLRDAKDVGVKKAISSNIAMGFTFLMIYLSYALAFWYGSTLILNFEYTIGN
MDR1_HUMAN      KKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQ
MDR1_LEIEN      DYELERFTKAVLYAQGRGIRKELASNLSAAVIMALMYVSYTVAFFFGSYLVEWGRRDMAD
MDR1_MOUSE      QKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGE
MDR1_RAT_       KKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGQ
MDR1_CRIGR      KKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQ
MDR1_CAEEL      RYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHDGSLNFGD
MDR3_HUMAN      NKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGN
MDR3_MOUSE      KKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQ
MDR3_CRIGR      NKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGN
MDR3_CAEEL      PFEINRYAHQLNEARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGA
                   . *.   .  *.  *. * .    .        . . ..**  *             

MDR1_FUGU_      LLTVFFVVLYGAYIIGQASPNVQSFASARGAAYKVYNIIDHKPNIDSFSEDGYKPEYIKG
MSR3_FUGU_      LLTVFFVVLIGAFSVGQTSPNIQNFASARGAAYKVYSIIDNKPNIDSFSEDGFKPDFIKG
MDR1_HUMAN      VLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKG
MDR1_LEIEN      IISTFLAVLMGSFGLGFVAPSRTAFTESRAAAYEIFKAIDRVPPVD-IDAGGVPVPGFKE
MDR1_MOUSE      VLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGYKPDSIMG
MDR1_RAT_       VLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPSIDSFSTKGHKPDSIMG
MDR1_CRIGR      VLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPDNIKG
MDR1_CAEEL      MLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKAGRKDMKIKG
MDR3_HUMAN      AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKG
MDR3_MOUSE      VLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQG
MDR3_CRIGR      AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKG
MDR3_CAEEL      VFAVFWAVLIGTRRLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQG
                  . *  .. *.  .*   *       .. *   ..  .*  * .      *        

MDR1_FUGU_      DIVFQNIHFSYPSRPEIKILNDMSFHVRNGQTIALVGSSGCGKSTTIQLLQRFYDPQKGS
MSR3_FUGU_      DIEFKNIHFNYPSRPEVKILNNMSLSVKSGQTIALVGSSGCGKSTTIQLLQRFYDPEEGA
MDR1_HUMAN      NLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGM
MDR1_LEIEN      SIEFRNVRFAYPTRPGMILFRDLSLKIKCGQKVAFSGASGCGKSSVIGLIQRFYDPIGGA
MDR1_MOUSE      NLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGV
MDR1_RAT_       NLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGE
MDR1_CRIGR      NLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGV
MDR1_CAEEL      DITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGK
MDR3_HUMAN      NLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGT
MDR3_MOUSE      NLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGM
MDR3_CRIGR      NLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDPTEGT
MDR3_CAEEL      KLTFDGIEFTYPTRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGM
                 .    . * **.*  . .   .   .  *. .*  * *****.. . *. * *    * 

MDR1_FUGU_      IFIDGHDIRSLNIRYLREMIGVVSQEPVLFATTITENIRYGRLDVTQEEIERATKESNAY
MSR3_FUGU_      VFIDGHDIRSLNIRYLREMIGVVSQEPVLFATTITENIRYGRLDVTQEEIERATKESNAY
MDR1_HUMAN      VSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAY
MDR1_LEIEN      VLVDGVRMRELCLREWRDQIGIVSQEPNLFAGTMMENVRMGKPNATDEEVVEACRQANIH
MDR1_MOUSE      VSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAY
MDR1_RAT_       VSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAY
MDR1_CRIGR      VSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAY
MDR1_CAEEL      ITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAE
MDR3_HUMAN      INIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAY
MDR3_MOUSE      VSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAY
MDR3_CRIGR      ISIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKAVKEANAY
MDR3_CAEEL      IKLDGIPIQEYNIRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAH
                . .**  ..   .   *  . .* *** .*  *. **.  *    *  ..  * . .*  

MDR1_FUGU_      DFIMNLPQKFETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQ
MSR3_FUGU_      DFIMNLPQKFETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQ
MDR1_HUMAN      DFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQ
MDR1_LEIEN      DTIMALPDRYDTPVGPVGSLLSGGQKQRIAIARALVKRPPILLLDEATSALDRKSEMEVQ
MDR1_MOUSE      DFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQ
MDR1_RAT_       DFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQ
MDR1_CRIGR      DFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQ
MDR1_CAEEL      KFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQ
MDR3_HUMAN      EFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQ
MDR3_MOUSE      DFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQ
MDR3_CRIGR      EFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQ
MDR3_CAEEL      EFICKLSDRYDTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQ
                  *  *   . * .*     ********.*****.*. * ************  **  **

MDR1_FUGU_      AALDKVRL--GRTTIVIAHRLSTIRNADIIA-----GFSNGEIVEQGTHSQLMEIK-GVY
MSR3_FUGU_      AALDKVRL--GRTTIVVAHRLSTIRNADIIA-----GFSNGKIVEQGTHSQLMEIK-GVY
MDR1_HUMAN      VALDKARK--GRTTIVIAHRLSTVRNADVIA-----GFDDGVIVEKGNHDELMKEK-GIY
MDR1_LEIEN      AALDQLIQRGGTTVVVIAHRLATIRDMDRIYYVKHDGAEGSRITESGTFDELLELD-GEF
MDR1_MOUSE      AALDKARE--GRTTIVIAHRLSTVRNADVIA-----GFDGGVIVEQGNHDELMREK-GIY
MDR1_RAT_       AALDKARE--GRTTIVIAHRLSTVRNADVIA-----GFDGGVIVEQGNHEELMKEK-GIY
MDR1_CRIGR      AALDKARE--GRTTIVIAHRLSTVRNADIIA-----GFDGGVIVEQGNHEELMREK-GIY
MDR1_CAEEL      QALDKAAK--GRTTIIIAHRLSTIRNADLII-----SCKNGQVVEVGDHRALMAQQ-GLY
MDR3_HUMAN      AALDKARE--GRTTIVIAHRLSTVRNADVIA-----GFEDGVIVEQGSHSELMKKE-GVY
MDR3_MOUSE      AALDKARE--GRTTIVIAHRLSTVRNADVIA-----GFDGGVIVEQGNHDELMREK-GIY
MDR3_CRIGR      AALDKARE--GRTTIVIAHRLSTVRNADVIA-----GFEDGVIVEQGSHSELMQKE-GVY
MDR3_CAEEL      TALDKASE--GRTTLCIAHRLSTIRNAS-------------------THDELISKDDGIY
                 ***.     * * . .****.*.*                          *.    * .

MDR1_FUGU_      HGLVTMQSFQK-LEDLEDSDYEP--------WVAEKSQLIESFSQSSLQRRRSTRGSLLA
MSR3_FUGU_      HGLVTMQTFHN-VEEENTAMSEL--------SAGEKSPVEKTVSQSSIIRRKSTRGSSFA
MDR1_HUMAN      FKLVTMQTAGNEVELENAADESK--------SEIDALEMSSNDSRSSLIRKRSTRRSVRG
MDR1_LEIEN      AAVAKMQGVLAGDAKSGASVRD---------AKKASGHLGVILDEADLAQLDEDVPRTAR
MDR1_MOUSE      FKLVMTQTRGNEIEPGNNAYGSQ--------SDTDASELTSEESKSPLIR-RSIYRSVHR
MDR1_RAT_       FKLVMTQTRGNEIEPGNNAYESQ--------SDTGASELTSEESKSPLIR-RSIRRSIHR
MDR1_CRIGR      FKLVMTQTAGNEIELGNEVGESK--------NEIDNLDMSSKDSASSLIRRRSTRRSIRG
MDR1_CAEEL      YDLVTAQTFTDAVDSAAEGKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSIT
MDR3_HUMAN      FKLVNMQTSGSQIQSEEFELND----------EKAATRMAPNGWKSRLFR-HSTQKNLKN
MDR3_MOUSE      FKLVMTQTAGNEIELGNEACKSK--------DEIDNLDMSSKDSGSSLIRRRSTRKSICG
MDR3_CRIGR      FKLVNMQTSGSQILSQEFEVELS--------EEKAADGMTPNGWKSHIFR-NSTKKSLKS
MDR3_CAEEL      ASMVKAQEIERAKEDTTLDDEEDEK-THRSFHRDSVTSDEERELQQSLAR-DSTRLRQSM
                  .   *                                        . .          

MDR1_FUGU_      V----SEGTKEEKEKFECDQDNIEEDENVPPVSFFKVMRYNVSEWPYILVGTICAMINGA
MSR3_FUGU_      A----SEGTKEEK---------TEEDEDVPDVSFFKVLHLNIPEWPYILVGLICATINGA
MDR1_HUMAN      S----QAQDRKLSTK-------EALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGG
MDR1_LEIEN      Q----NVPIDELAK----------WEVKHAKVGFLRLMRMNKDKAWAVALGILSSVVIGS
MDR1_MOUSE      K----QDQERRLSMK-------EAVDEDVPLVSFWRILNLNLSEWPYLLVGVLCAVINGC
MDR1_RAT_       R----QDQERRLSSK-------EDVDEDVPMVSFWQILKLNISEWPYLVVGVLCAVINGC
MDR1_CRIGR      P----HDQDRKLSTK-------EALDEDVPPISFWRILKLNSSEWPYFVVGIFCAIVNGA
MDR1_CAEEL      NGPVIDEKEERIGKDALSRLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGF
MDR3_HUMAN      S----QMCQKSLDVET------DGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGG
MDR3_MOUSE      P----HDQDRKLSTK-------EALDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGG
MDR3_CRIGR      S----RAHHHRLDVDA------DELDANVPPVSFLKVLKLNKTEWPYFVVGTVCAIVNGA
MDR3_CAEEL      ISTTTQVPEWEIENAR-----EEMIEEGAMEASLFDIFKYASPEMRNIIISLVFTLIRGF
                                         .          .            .    .   * 

MDR1_FUGU_      MQPVFSIIFTEII-----------------------------------------------
MSR3_FUGU_      MQPVFAILFSKIITVF---ADPDR-DSVRRKSEFISLMFVVIGCVSFVTMFLQGYCFGKS
MDR1_HUMAN      LQPAFAIIFSKIIGVF---TRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA
MDR1_LEIEN      ARPASSIVMGHMLRVLGEYSATKDVEALRSGTNLYAPLFIVFAVANFSGWILHG-FYGYA
MDR1_MOUSE      IQPVFAIVFSRIVGVF---SRDDDHETKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKA
MDR1_RAT_       IQPVFAIVFSKIVGVF---SRDDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKA
MDR1_CRIGR      LQPAFSIIFSKVVGVF---TRNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKA
MDR1_CAEEL      IYPTYSVFFTSFMNVF---AG--NPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIA
MDR3_HUMAN      LQPAFSVIFSEIIAIF---GPGDD-AVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKA
MDR3_MOUSE      LQPAFSVIFSKVVGVF---TNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKA
MDR3_CRIGR      LQPAISIILSEMIAIF---GPGDD-AVKQQKCNLFSLVFLGLGVLSFFTFFLQGFTFGKA
MDR3_CAEEL      TWPAFSIVYGQLFKIL---SAGGD--DVSIKALLNSLWFILLAFTGGISTLISGSLLGKA
                  *  ..                                                     

MDR1_FUGU_      ------------------MDLSWYDNPKNTVGALTTRLAADAAHVQGAAGVRLAVMTQNF
MSR3_FUGU_      GEILTLKLRLRAFTAMMRQDLSWYDNPQNTVGALTTRLAADAAQVQGAAGVRLATIMQNF
MDR1_HUMAN      GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI
MDR1_LEIEN      GEHLTTKIRVLLFRQIMRQDINFFDIPGRDAGTLAGMLSGDCEAVHQLWGPSIGLKVQTM
MDR1_MOUSE      GEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTTRLASDASSVKGAMGARLAVVTQNV
MDR1_RAT_       GEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNV
MDR1_CRIGR      GEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAGQVKGATGARLAVITQNI
MDR1_CAEEL      SESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTL
MDR3_HUMAN      GEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNI
MDR3_MOUSE      GEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNI
MDR3_CRIGR      GEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGALSTRLATDRAQVQGATGTRLALIAQNT
MDR3_CAEEL      GETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGI
                                       .*      * ..  *. *   ..              

MDR1_FUGU_      ANLGTSIIIS--FVYGWELTLLILAVVPILAVAGAAEVKLLTGHAAEDKKELEMAGKIAT
MSR3_FUGU_      ANLGTSIIIA--FVYGWELTLLILAVVPLIAAAGAAEIKLLAGHAAKDKKELEKAGKIAT
MDR1_HUMAN      ANLGTGIIIS--FIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIAT
MDR1_LEIEN      CIIASGLVVG--FIYQWKLALVALACMPLMIGCSLTRRLMINGYTK--SREGDTDDTIVT
MDR1_MOUSE      ANLGTGVILS--LVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKQLEISGKIAT
MDR1_RAT_       ANLGTGIILSLVLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKELEISGKIAT
MDR1_CRIGR      ANLGTGIIIS--LIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIAT
MDR1_CAEEL      VSMVAGIGLA--FFYGWQMALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAI
MDR3_HUMAN      ANLGTGIIIS--FIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIAT
MDR3_MOUSE      ANLGTGIIIS--LIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIAT
MDR3_CRIGR      ANLGTGIIIS--FIYGWQLTLLLLSVVPFIAVSGIVEMKMLAGNAKRDKKALEAAGKIAT
MDR3_CAEEL      VSLFCGVGVA--FYYGWNMAPIGLATELLLVVVQSSVAQYLKFRGQRDMDSAIEASRLVT
                  . . . .     * * .. . .     .                           .  

MDR1_FUGU_      EAIENVRTVVSLTREPTFVALYEENLTVPYKNSQKKAKIYGLTYSFSQAMIFFVYAACFR
MSR3_FUGU_      EAIENVRTVVSLSREPKFECLYEENLRVPYKNSQKKAHVYGLTYSFSQAMIYFAYAACFR
MDR1_HUMAN      EAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFR
MDR1_LEIEN      EALSNVRTVTSLNMKEDCVEAFQAALREEAPRSVRKGIIAGGIYGITQFIFYGVYALCFW
MDR1_MOUSE      EAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGITFSFTQAMMYFSYAACFR
MDR1_RAT_       EAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFAFTQAMIYFSYAACFR
MDR1_CRIGR      EAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFR
MDR1_CAEEL      EAIENVRTVQALAREDTFYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYR
MDR3_HUMAN      EAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFR
MDR3_MOUSE      EAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFFFTQAMMYFSYAACFR
MDR3_CRIGR      EAIENIRTVVSLTQERKFESMYVEKLHEPYRNSVQMAHIYGITFSISQAFMYFSYAGCFR
MDR3_CAEEL      ESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYM
                *.. * .*. .*         .          .          .  .        . .. 

MDR1_FUGU_      FGAWLIEAG--RMDVEGVFLVVMTMLYGAMAVGEANTYAPNFAKAKISASHLTMLINRQP
MSR3_FUGU_      FGAWLIEAG--RMDVEGVFLVVSAVLYGAMAVGEANTFAPNYAKAKMAASYLMMLINKKP
MDR1_HUMAN      FGAYLVAHK--LMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTP
MDR1_LEIEN      YGSKLIDKG--EAEFKDVMIASMSILFGAQNAGEAGAFATKLADAEASAKRVFSVIDRVP
MDR1_MOUSE      FGAYLVAQQ--LMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKTP
MDR1_RAT_       FGAYLVARE--LMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIGIIEKIP
MDR1_CRIGR      FGAYLVARE--LMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKVP
MDR1_CAEEL      MGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKIS
MDR3_HUMAN      FGAYLIVNG--HMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQP
MDR3_MOUSE      FGAYLVTQQ--LMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTP
MDR3_CRIGR      FGAYLIVNG--HMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFSLFERQP
MDR3_CAEEL      FGLWLISNN--WSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKS
                 *  *.           *     ..   .       ..      *  .   .  .  .  

MDR1_FUGU_      AIDNLSEEEARLEKYDGNVLFEDVKFNYPSRPDVPVLQGLNLEVQKGETLALVGSSGCGK
MSR3_FUGU_      AIDNLSEEGTSPEKYDGNVHFEGVKFNYPSRPDVTILQGLNLKVKKGETLALVGSSGCGK
MDR1_HUMAN      LIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGK
MDR1_LEIEN      DVD-IEQAGNKDLGEGCDIEYRNVQFIYSARPKQVVLASVNMRFGDATSNGLIGQTGCGK
MDR1_MOUSE      EIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGK
MDR1_RAT_       EIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPNIPVLQGLSFEVKKGQTLRLVGSSGCGK
MDR1_CRIGR      SIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCGK
MDR1_CAEEL      KIDSLSLAGEK-KKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGK
MDR3_HUMAN      LIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGK
MDR3_MOUSE      EIDSYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGK
MDR3_CRIGR      LIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQGLSLEVKKGQTLALVGSSGCGK
MDR3_CAEEL      VIDNRGLTGDT-PTIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGK
                 .*               .      * *  *    .*           .  *.* .****

MDR1_FUGU_      STTIQLLERFYDPREGRVLLDGVDVKQLNVHWLRSQIGIVSQEPVLFDCSLAENIAYGDN
MSR3_FUGU_      STTIQLLERFYDPREGRVSLDGVNVKQLNIHWLRSQIGIVSQEPVLFDCSLAENIAYGDN
MDR1_HUMAN      STVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDN
MDR1_LEIEN      STVIQMLARFYERRSGLISVNGRDLSSLDIAEWRRNISIVLQEPNLFSGTVRENIRYARE
MDR1_MOUSE      STVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDN
MDR1_RAT_       STVVQLLERFYNPMAGTVFLDGKEIKQLNVQCVRA-LGIVSQEPILFDCSIAENIAYGDN
MDR1_CRIGR      STVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDN
MDR1_CAEEL      STVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLD
MDR3_HUMAN      STVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDN
MDR3_MOUSE      STVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDN
MDR3_CRIGR      STVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLGIVSQEPVLFDCSIAENIAYGDN
MDR3_CAEEL      STTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLE
                ** . .. *.*    * . .       *     *  . .* *** **  .. *** *   

MDR1_FUGU_      SRSVSMDEIVAAAKAANIHSFIEGLPQRYDTQAGDKGTQLSGGQKQRVAIARAIIRNPKL
MSR3_FUGU_      SRSVSMDEI-----------------R-YDTQAGDKGTQLSGGQKQRVAIARAIIRNPKL
MDR1_HUMAN      SRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHI
MDR1_LEIEN      G--ATDEEVEEAARLAHIHHEIIKWTDGYDTEVGYKGRALSGGQKQRIAIARGLLRRPRL
MDR1_MOUSE      SRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHI
MDR1_RAT_       SRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHI
MDR1_CRIGR      SRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHI
MDR1_CAEEL      PSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKI
MDR3_HUMAN      SRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQI
MDR3_MOUSE      SRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHI
MDR3_CRIGR      SRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGTQLSGGQKQRLAIRRALIRQPRV
MDR3_CAEEL      N--ITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKI
                    .  ..                   . *  *  *  ********.** * ..* *..

MDR1_FUGU_      LLLDEATSALDTESEKVVQEALD--QARKGRTCIVVAHRLSTIQNADCIAVFQGGVVVEK
MSR3_FUGU_      LLLDEATSALDTESEKVVQEALD--QARKGRTCIVVAHRLSTIQNADCIAVFQGGVVVEK
MDR1_HUMAN      LLLDEATSALDTESEKVVQEALD--KAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH
MDR1_LEIEN      LLLDEATSALDSVTEAKVQEGIEAFQAKYKVTTVSIAHRLTTIRHCDQIILLDSGCIIEQ
MDR1_MOUSE      LLLDEATSALDTESEKVVQEALD--KAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEH
MDR1_RAT_       LLLDEATSALDTESEKVVQEALD--KAREGRTCVVIAHRLSTIQNADLIVVIQNGQVKEH
MDR1_CRIGR      LLLDEATSALDTESEKVVQEALD--KAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEH
MDR1_CAEEL      LLLDEATSALDTESEKVVQEALD--RAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEK
MDR3_HUMAN      LLLDEATSALDTESEKVVQEALD--KAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH
MDR3_MOUSE      LLLDEATSALDTESEKVVQEALD--KAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEH
MDR3_CRIGR      LLLDEATSALDTESEKVVQEALD--KAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEH
MDR3_CAEEL      LLLDEATSALDTESEKIVQEALD--KARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEE
                ***********. .*  *** ..  .*.   *.. .**** *. ..* * .   *   * 

MDR1_FUGU_      GTHQQLIAKKGVYHMLVTKQMGYHSG
MSR3_FUGU_      GTHQQLIAKKGVYHMLVTKQMGYHND
MDR1_HUMAN      GTHQQLLAQKGIYFSMVSVQAGTKRQ
MDR1_LEIEN      GSHEELMALGGEYKTRYDLYMSALS-
MDR1_MOUSE      GTHQQLLAQKGIYFSMV--QAGAKRS
MDR1_RAT_       GTHQQLLAQKGIYFSMV--QAGAKRS
MDR1_CRIGR      GTHQQLLAQKGIYFSMVSVQAGAKR-
MDR1_CAEEL      GTHTQLMSEKGAYYKLTQKQMTEKK-
MDR3_HUMAN      GTHQQLLAQKGIYFSMVSVQAGTQNL
MDR3_MOUSE      GTHQQLLAQKGIYFSMVSVQAGAKRS
MDR3_CRIGR      GTHQQLLAQKGIYFSMVNIQAGAQNS
MDR3_CAEEL      GTHQTLLARRGLYYRLVEKQSS----
                *.*  *..  * *