Align-AA3

CLUSTAL W(1.60) multiple sequence alignment



MDR1_FUGU_      ------------------------------------------------------------
MSR3_FUGU_      ----------------MALKIDTAETNGDLSHDSKDDGAKNEKK--KKNKKEKPPQEPMV
MDR1_HUMAN      ------------------MDLEGDRNGG-----AKKKNFFKLN---NKSEKDKKEKKPTV
MDR1_LEIEN      -----MSRAHAAYANEGWSAPEGGIAGKDGSTRDCSGYGSQGPLFSAEEEVKGTVVRETV
MDR1_MOUSE      ------------------MEFEENLKG------RADKNFSKMG---KKSKKEKKEKKPAV
MDR1_RAT_       ------------------MEFEEGLNG------RADKNFSKMG---KKSKKEK-EKKPAV
MDR1_CRIGR      ------------------MEFEEDFSG------RKDKNFLKMG---RKSKKEKKEKKPVV
MDR1_CAEEL      MLRNGSLRQSLRTLDSFSLAPEDVLKTAIKTVEDYEGDNIDSNGEIKITRDAKEEVVNKV
MDR3_HUMAN      ------------------MDLEAAKNGTAWRPTSAEGDFELGIS--SKQKRKKTKTVKMI
MDR3_MOUSE      ------------------MELEEDLKG------RADKNFSKMG---KKSKKEKKEKKPAV
MDR3_CRIGR      ------------------MDLEAARNGTARRPGTVEGDFELGSI--SNQGRNKKKKVNLI
MDR3_CAEEL      --------------------MKKTKVN------PED--DITLG---KFTPKPSPQDSYQG
                                                                            

MDR1_FUGU_      ----------------------MAIVNGLVNPLMCIVFGEMTDSFIQ---EA--KLSQN-
MSR3_FUGU_      GPITLFRFADRWDVVLLISGTVMAMVNGTVMPLMCIVFGEMTDSFIY---AD--MAQHN-
MDR1_HUMAN      SVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFA--NAGNLEDLMSNI
MDR1_LEIEN      GPIEIFRYADATDRVLMIAGTAFAVACGAGMPVFSFIFGRIAMDLMS-------------
MDR1_MOUSE      GVFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFT-KAEASILPSITN-
MDR1_RAT_       GIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTPSRDPHSDRAITN-
MDR1_CRIGR      SVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFA--SVGNIPTNATNN
MDR1_CAEEL      SIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFIN------EQIVINN
MDR3_HUMAN      GVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVD--------TAGNF
MDR3_MOUSE      SVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFA--SVGNVSKNSTN-
MDR3_CRIGR      GPLTLFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMIVFGEMTDKFVN--------NAGNF
MDR3_CAEEL      NFFDVFRDADYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALME-------------
                                       .   *   *    .   ..                  

MDR1_FUGU_      --HNTSNPR---ANSTLEADMQRFSIYYSILGFAVLVVAYLQMSLWTLTAARQAKRIREL
MSR3_FUGU_      --ASGWNSTTTILNSTLQEDMQRFAIYYSVLGFVVLLAAYMQVSFWTITAGRQVKRIRSL
MDR1_HUMAN      TNRSDINDTGFFMN--LEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQ
MDR1_LEIEN      ------------GVGSAEEKAAKTSLIMVYVGIAMLIACAGHVMCWTVAACRQVARIRLL
MDR1_MOUSE      --QSGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQK
MDR1_RAT_       --QSEINSTHTVSDTSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQK
MDR1_CRIGR      --ATQVNASDIFGK--LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQK
MDR1_CAEEL      NGSTFLPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQIIVTCYLYVAEQMNNRLRRE
MDR3_HUMAN      SFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQK
MDR3_MOUSE      --MSEADKRAMFAK--LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQK
MDR3_CRIGR      SLPVNFSLSMINPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQN
MDR3_CAEEL      --GESQYQNGTINMPWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKK
                                              .   .              . .    .*  

MDR1_FUGU_      FFHGIMQQDISWYDVTETGELNTRLTEWVTHIIHTPVPVTAGVVVIICGVRFPGAHDVYK
MSR3_FUGU_      FFHCIMQQEISWFDVNDTGELNTRLTD-----------------------------DVYK
MDR1_HUMAN      FFHAIMRQEIGWFDVHDVGELNTRLTD-----------------------------DVSK
MDR1_LEIEN      FFRAVLRQDIGWHDEHSPGALTARMTG-----------------------------DTRV
MDR1_MOUSE      FFHAIMNQEIGWFDVHDVGELNTRLTD-----------------------------DVSK
MDR1_RAT_       FFHAIMNQEIGWFDVNDAGELNTRLTD-----------------------------DVSK
MDR1_CRIGR      FFHAIMNQEIGWFDVHDVGELNTRLTD-----------------------------DVSK
MDR1_CAEEL      FVKSILRQEISWFDTNHSGTLATKLFD-----------------------------NLER
MDR3_HUMAN      FFHAILRQEIGWFDINDTTELNTRLTD-----------------------------DISK
MDR3_MOUSE      FFHAIMNQEIGWFDVHDVGELNTRLTD-----------------------------DVSK
MDR3_CRIGR      FFHAILRQEMGWFDIKGTTELNTRLTD-----------------------------DISK
MDR3_CAEEL      YLKSVLRQDAKWFDETTIGGLTQKMSS-----------------------------GIEK
                . . .. *.  * *      *  ..                                   

MDR1_FUGU_      IQEGIGDKAGLLIQAASTFITSFVIGFVHGWKLTLVILAISPVLGLSAALYSKLLTSFTS
MSR3_FUGU_      IQEGIGDKVGLLIQAYTTFITAFIIGFTTGWKLTLVILAVSPALAISAAFFSKVLASFTS
MDR1_HUMAN      INEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTD
MDR1_LEIEN      IQNGINDKLSQGIMNGSMGVIGYIAGFVFSWELTLMMIGMMPFIIVMAAIIGSIVSKITE
MDR1_MOUSE      INDGIGDKIGMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTN
MDR1_RAT_       INDGIGDKLGMFFQSITTFSAGFIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTN
MDR1_CRIGR      INEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTD
MDR1_CAEEL      VKEGTGDKIGMAFQYLSQFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAI
MDR3_HUMAN      ISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSD
MDR3_MOUSE      INEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTD
MDR3_CRIGR      ISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSTFSD
MDR3_CAEEL      IKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITVPLQLGSMYLSAKHLNRATK
                .  * .**        .         *   * ***...   *            .   . 

MDR1_FUGU_      KEQTAYAKAGAVAAEVLSSIRTVFAFSGQRKAIKRYHKNLEDARDMGIKKGVAANTATGF
MSR3_FUGU_      KEQTAYAKAGAVAEEVLSAIRTVFAFSGQTREIERYHKNLRDAKDVGVKKAISSNIAMGF
MDR1_HUMAN      KELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGA
MDR1_LEIEN      SSRKYFAKAGSLATEVMENIRTVQAFGREDYELERFTKAVLYAQGRGIRKELASNLSAAV
MDR1_MOUSE      KELQAYAKAGAVAEEVLAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGI
MDR1_RAT_       KELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGI
MDR1_CRIGR      KELQAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGA
MDR1_CAEEL      RETLRYAKAGKVVEETISSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGA
MDR3_HUMAN      KELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGI
MDR3_MOUSE      KELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGA
MDR3_CRIGR      KELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGI
MDR3_CAEEL      NEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEARRMGIRKAIILAICTAF
                     .. ** .  * .  **** .       . *.   .  *.  *. * .    .   

MDR1_FUGU_      SFLMIYLSYALAFWYGTTLVLNKEYTIGNLLTVFFVVLYGAYIIGQASPNVQSFASARGA
MSR3_FUGU_      TFLMIYLSYALAFWYGSTLILNFEYTIGNLLTVFFVVLIGAFSVGQTSPNIQNFASARGA
MDR1_HUMAN      AFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGA
MDR1_LEIEN      IMALMYVSYTVAFFFGSYLVEWGRRDMADIISTFLAVLMGSFGLGFVAPSRTAFTESRAA
MDR1_MOUSE      AYLLVYASYALAFWYGTSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGA
MDR1_RAT_       AYLLVYASYALAFWYGTSLVLSNEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGA
MDR1_CRIGR      AFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFAVLIGAFSIGQASPNIEAFANARGA
MDR1_CAEEL      MQASNFISFALAFYIGVGWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGA
MDR3_HUMAN      AFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGA
MDR3_MOUSE      AFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGA
MDR3_CRIGR      AFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGA
MDR3_CAEEL      PLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTRRLGEAAPHLGAITGARLA
                     . . ..**  *               . *  .. *.  .*   *       .. *

MDR1_FUGU_      AYKVYNIIDHKPNIDSFSEDGYKPEYIKGDIVFQNIHFSYPSRPEIKILNDMSFHVRNGQ
MSR3_FUGU_      AYKVYSIIDNKPNIDSFSEDGFKPDFIKGDIEFKNIHFNYPSRPEVKILNNMSLSVKSGQ
MDR1_HUMAN      AYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQ
MDR1_LEIEN      AYEIFKAIDRVPPVD-IDAGGVPVPGFKESIEFRNVRFAYPTRPGMILFRDLSLKIKCGQ
MDR1_MOUSE      AFEIFKIIDNEPSIDSFSTKGYKPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQ
MDR1_RAT_       AYEIFKIIDNEPSIDSFSTKGHKPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQ
MDR1_CRIGR      AYEIFNIIDNKPSIDSFSKNGYKPDNIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQ
MDR1_CAEEL      ASGIYEVLDRKPVIDSSSKAGRKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQ
MDR3_HUMAN      AYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQ
MDR3_MOUSE      AYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQ
MDR3_CRIGR      AYVIFDIIDNNPKIDSFSERGHKPDSIKGNLDFSDVHFSYPSRANIKILKGLNLKVQSGQ
MDR3_CAEEL      IHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPTRPELKILKGVSFEVNPGE
                   ..  .*  * .      *         .    . * **.*  . .   .   .  *.

MDR1_FUGU_      TIALVGSSGCGKSTTIQLLQRFYDPQKGSIFIDGHDIRSLNIRYLREMIGVVSQEPVLFA
MSR3_FUGU_      TIALVGSSGCGKSTTIQLLQRFYDPEEGAVFIDGHDIRSLNIRYLREMIGVVSQEPVLFA
MDR1_HUMAN      TVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFA
MDR1_LEIEN      KVAFSGASGCGKSSVIGLIQRFYDPIGGAVLVDGVRMRELCLREWRDQIGIVSQEPNLFA
MDR1_MOUSE      TVALVGNSGCGKSTTVQLMQRLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFA
MDR1_RAT_       TVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFA
MDR1_CRIGR      TVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFA
MDR1_CAEEL      TVALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFN
MDR3_HUMAN      TVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFS
MDR3_MOUSE      TVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFA
MDR3_CRIGR      TVALVGNSGCGKTTTLQLLQRLYDPTEGTISIDGQDIRNFNVRYLREIIGVVSQEPVLFS
MDR3_CAEEL      TVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRSTIGIVQQEPIIFV
                 .*  * *****.. . *. * *    * . .**  ..   .   *  . .* *** .* 

MDR1_FUGU_      TTITENIRYGRLDVTQEEIERATKESNAYDFIMNLPDVRPHLWLPYLSLAPSRSNANIYI
MSR3_FUGU_      TTITENIRYGRLDVTQEEIERATKESNAYDFIMNLPDVRPHLWLPYLSLAPSRSNANIYI
MDR1_HUMAN      TTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLP------------------------
MDR1_LEIEN      GTMMENVRMGKPNATDEEVVEACRQANIHDTIMALP------------------------
MDR1_MOUSE      TTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLP------------------------
MDR1_RAT_       TTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLP------------------------
MDR1_CRIGR      TTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLP------------------------
MDR1_CAEEL      CTIEENISLGKEGITREEMVAACKMANAEKFIKTLP------------------------
MDR3_HUMAN      TTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLP------------------------
MDR3_MOUSE      TTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLP------------------------
MDR3_CRIGR      TTIAENIRYGRGNVTMEEIKKAVKEANAYEFIMKLP------------------------
MDR3_CAEEL      ATVAENIRMGDVLITDQDIEEACKMANAHEFICKLS------------------------
                 *. **.  *    *  ..  * . .*    *  *                         

MDR1_FUGU_      MISEQKFETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAAL
MSR3_FUGU_      MISEQKFETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAAL
MDR1_HUMAN      ----HKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVAL
MDR1_LEIEN      ----DRYDTPVGPVGSLLSGGQKQRIAIARALVKRPPILLLDEATSALDRKSEMEVQAAL
MDR1_MOUSE      ----HQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL
MDR1_RAT_       ----HKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL
MDR1_CRIGR      ----HKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL
MDR1_CAEEL      ----NGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQAL
MDR3_HUMAN      ----QKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAAL
MDR3_MOUSE      ----HQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAAL
MDR3_CRIGR      ----QKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAAL
MDR3_CAEEL      ----DRYDTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTAL
                      . * .*     ********.*****.*. * ************  **  ** **

MDR1_FUGU_      DKVRL--GRTTIVIAHRLSTIRNADIIA-----GFSNGEIVEQGTHSQLMEIK-GVYHGL
MSR3_FUGU_      DKVRL--GRTTIVVAHRLSTIRNADIIA-----GFSNGKIVEQGTHSQLMEIK-GVYHGL
MDR1_HUMAN      DKARK--GRTTIVIAHRLSTVRNADVIA-----GFDDGVIVEKGNHDELMKEK-GIYFKL
MDR1_LEIEN      DQLIQRGGTTVVVIAHRLATIRDMDRIYYVKHDGAEGSRITESGTFDELLELD-GEFAAV
MDR1_MOUSE      DKARE--GRTTIVIAHRLSTVRNADVIA-----GFDGGVIVEQGNHDELMREK-GIYFKL
MDR1_RAT_       DKARE--GRTTIVIAHRLSTVRNADVIA-----GFDGGVIVEQGNHEELMKEK-GIYFKL
MDR1_CRIGR      DKARE--GRTTIVIAHRLSTVRNADIIA-----GFDGGVIVEQGNHEELMREK-GIYFKL
MDR1_CAEEL      DKAAK--GRTTIIIAHRLSTIRNADLII-----SCKNGQVVEVGDHRALMAQQ-GLYYDL
MDR3_HUMAN      DKARE--GRTTIVIAHRLSTVRNADVIA-----GFEDGVIVEQGSHSELMKKE-GVYFKL
MDR3_MOUSE      DKARE--GRTTIVIAHRLSTVRNADVIA-----GFDGGVIVEQGNHDELMREK-GIYFKL
MDR3_CRIGR      DKARE--GRTTIVIAHRLSTVRNADVIA-----GFEDGVIVEQGSHSELMQKE-GVYFKL
MDR3_CAEEL      DKASE--GRTTLCIAHRLSTIRNAS-------------------THDELISKDDGIYASM
                *.     * * . .****.*.*                          *.    * .  .

MDR1_FUGU_      VTMQSFQK-LEDLEDSDYEP--------WVAEKSQLIESFSQSSLQRRRSTRGSLLAV--
MSR3_FUGU_      VTMQTFHN-VEEENTAMSEL--------SAGEKSPVEKTVSQSSIIRRKSTRGSSFAA--
MDR1_HUMAN      VTMQTAGNEVELENAADESK--------SEIDALEMSSNDSRSSLIRKRSTRRSVRGS--
MDR1_LEIEN      AKMQGVLAGDAKSGASVRD---------AKKASGHLGVILDEADLAQLDEDVPRTARQ--
MDR1_MOUSE      VMTQTRGNEIEPGNNAYGSQ--------SDTDASELTSEESKSPLIR-RSIYRSVHRK--
MDR1_RAT_       VMTQTRGNEIEPGNNAYESQ--------SDTGASELTSEESKSPLIR-RSIRRSIHRR--
MDR1_CRIGR      VMTQTAGNEIELGNEVGESK--------NEIDNLDMSSKDSASSLIRRRSTRRSIRGP--
MDR1_CAEEL      VTAQTFTDAVDSAAEGKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGP
MDR3_HUMAN      VNMQTSGSQIQSEEFELND----------EKAATRMAPNGWKSRLFR-HSTQKNLKNS--
MDR3_MOUSE      VMTQTAGNEIELGNEACKSK--------DEIDNLDMSSKDSGSSLIRRRSTRKSICGP--
MDR3_CRIGR      VNMQTSGSQILSQEFEVELS--------EEKAADGMTPNGWKSHIFR-NSTKKSLKSS--
MDR3_CAEEL      VKAQEIERAKEDTTLDDEEDEK-THRSFHRDSVTSDEERELQQSLAR-DSTRLRQSMIST
                   *                                        . .             

MDR1_FUGU_      --SEGTKEEKEKFECDQDNIEEDENVPPVSFFKVMRYNVSEWPYILVGTICAMINGAMQP
MSR3_FUGU_      --SEGTKEEK---------TEEDEDVPDVSFFKVLHLNIPEWPYILVGLICATINGAMQP
MDR1_HUMAN      --QAQDRKLSTK-------EALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQP
MDR1_LEIEN      --NVPIDELAK----------WEVKHAKVGFLRLMRMNKDKAWAVALGILSSVVIGSARP
MDR1_MOUSE      --QDQERRLSMK-------EAVDEDVPLVSFWRILNLNLSEWPYLLVGVLCAVINGCIQP
MDR1_RAT_       --QDQERRLSSK-------EDVDEDVPMVSFWQILKLNISEWPYLVVGVLCAVINGCIQP
MDR1_CRIGR      --HDQDRKLSTK-------EALDEDVPPISFWRILKLNSSEWPYFVVGIFCAIVNGALQP
MDR1_CAEEL      VIDEKEERIGKDALSRLKQELEENNAQKTNLFEILYHARPHALSLFIGMSTATIGGFIYP
MDR3_HUMAN      --QMCQKSLDVET------DGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQP
MDR3_MOUSE      --HDQDRKLSTK-------EALDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQP
MDR3_CRIGR      --RAHHHRLDVDA------DELDANVPPVSFLKVLKLNKTEWPYFVVGTVCAIVNGALQP
MDR3_CAEEL      TTQVPEWEIENAR-----EEMIEEGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWP
                                      .          .            .    .   *   *

MDR1_FUGU_      VFSIIFTEII--------------------------------------------------
MSR3_FUGU_      VFAILFSKIITVF---ADPDR-DSVRRKSEFISLMFVVIGCVSFVTMFLQGYCFGKSGEI
MDR1_HUMAN      AFAIIFSKIIGVF---TRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEI
MDR1_LEIEN      ASSIVMGHMLRVLGEYSATKDVEALRSGTNLYAPLFIVFAVANFSGWILHG-FYGYAGEH
MDR1_MOUSE      VFAIVFSRIVGVF---SRDDDHETKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEI
MDR1_RAT_       VFAIVFSKIVGVF---SRDDDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEI
MDR1_CRIGR      AFSIIFSKVVGVF---TRNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEI
MDR1_CAEEL      TYSVFFTSFMNVF---AG--NPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASES
MDR3_HUMAN      AFSVIFSEIIAIF---GPGDD-AVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEI
MDR3_MOUSE      AFSVIFSKVVGVF---TNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEI
MDR3_CRIGR      AISIILSEMIAIF---GPGDD-AVKQQKCNLFSLVFLGLGVLSFFTFFLQGFTFGKAGEI
MDR3_CAEEL      AFSIVYGQLFKIL---SAGGD--DVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGET
                  ..                                                        

MDR1_FUGU_      ---------------MDLSWYDNPKNTVGALTTRLAADAAHVQGAAGVRLAVMTQNFANL
MSR3_FUGU_      LTLKLRLRAFTAMMRQDLSWYDNPQNTVGALTTRLAADAAQVQGAAGVRLATIMQNFANL
MDR1_HUMAN      LTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANL
MDR1_LEIEN      LTTKIRVLLFRQIMRQDINFFDIPGRDAGTLAGMLSGDCEAVHQLWGPSIGLKVQTMCII
MDR1_MOUSE      LTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTTRLASDASSVKGAMGARLAVVTQNVANL
MDR1_RAT_       LTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANL
MDR1_CRIGR      LTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANL
MDR1_CAEEL      LTRDLRNKLFRNVLSQHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSM
MDR3_HUMAN      LTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANL
MDR3_MOUSE      LTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANL
MDR3_CRIGR      LTTRLRSMAFKAMLRQDMSWFDDYKNSTGALSTRLATDRAQVQGATGTRLALIAQNTANL
MDR3_CAEEL      MSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSL
                                    .*      * ..  *. *   ..                .

MDR1_FUGU_      GTSIIIS--FVYGWELTLLILAVVPILAVAGAAEVKLLTGHAAEDKKELEMAGKIATEAI
MSR3_FUGU_      GTSIIIA--FVYGWELTLLILAVVPLIAAAGAAEIKLLAGHAAKDKKELEKAGKIATEAI
MDR1_HUMAN      GTGIIIS--FIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAI
MDR1_LEIEN      ASGLVVG--FIYQWKLALVALACMPLMIGCSLTRRLMINGYTK--SREGDTDDTIVTEAL
MDR1_MOUSE      GTGVILS--LVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKQLEISGKIATEAI
MDR1_RAT_       GTGIILSLVLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKELEISGKIATEAI
MDR1_CRIGR      GTGIIIS--LIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAI
MDR1_CAEEL      VAGIGLA--FFYGWQMALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAI
MDR3_HUMAN      GTGIIIS--FIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI
MDR3_MOUSE      GTGIIIS--LIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAI
MDR3_CRIGR      GTGIIIS--FIYGWQLTLLLLSVVPFIAVSGIVEMKMLAGNAKRDKKALEAAGKIATEAI
MDR3_CAEEL      FCGVGVA--FYYGWNMAPIGLATELLLVVVQSSVAQYLKFRGQRDMDSAIEASRLVTESI
                 . . .     * * .. . .     .                           .  *..

MDR1_FUGU_      ENVRTVVSLTREPTFVALYEENLTVPYKNSQKKAKIYGLTYSFSQAMIFFVYAACFRFGA
MSR3_FUGU_      ENVRTVVSLSREPKFECLYEENLRVPYKNSQKKAHVYGLTYSFSQAMIYFAYAACFRFGA
MDR1_HUMAN      ENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGA
MDR1_LEIEN      SNVRTVTSLNMKEDCVEAFQAALREEAPRSVRKGIIAGGIYGITQFIFYGVYALCFWYGS
MDR1_MOUSE      ENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGA
MDR1_RAT_       ENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFAFTQAMIYFSYAACFRFGA
MDR1_CRIGR      ENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGA
MDR1_CAEEL      ENVRTVQALAREDTFYENFCEKLDIPHKEAIKEAFIQGLSYGCASSVLYLLNTCAYRMGL
MDR3_HUMAN      ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA
MDR3_MOUSE      ENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFFFTQAMMYFSYAACFRFGA
MDR3_CRIGR      ENIRTVVSLTQERKFESMYVEKLHEPYRNSVQMAHIYGITFSISQAFMYFSYAGCFRFGA
MDR3_CAEEL      SNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGL
                 * .*. .*         .          .          .  .        . ..  * 

MDR1_FUGU_      WLIEAG--RMDVEGVFLVVMTMLYGAMAVGEANTYAPNFAKAKISASHLTMLINRQPAID
MSR3_FUGU_      WLIEAG--RMDVEGVFLVVSAVLYGAMAVGEANTFAPNYAKAKMAASYLMMLINKKPAID
MDR1_HUMAN      YLVAHK--LMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLID
MDR1_LEIEN      KLIDKG--EAEFKDVMIASMSILFGAQNAGEAGAFATKLADAEASAKRVFSVIDRVPDVD
MDR1_MOUSE      YLVAQQ--LMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKTPEID
MDR1_RAT_       YLVARE--LMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIGIIEKIPEID
MDR1_CRIGR      YLVARE--LMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSID
MDR1_CAEEL      ALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKID
MDR3_HUMAN      YLIVNG--HMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLID
MDR3_MOUSE      YLVTQQ--LMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEID
MDR3_CRIGR      YLIVNG--HMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFSLFERQPLID
MDR3_CAEEL      WLISNN--WSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVID
                 *.           *     ..   .       ..      *  .   .  .  .   .*

MDR1_FUGU_      NLSEEEARLEKYDGNVLFEDVKFNYPSRPDVPVLQGLNLEVQKGETLALVGSSGCGKSTT
MSR3_FUGU_      NLSEEGTSPEKYDGNVHFEGVKFNYPSRPDVTILQGLNLKVKKGETLALVGSSGCGKSTT
MDR1_HUMAN      SYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTV
MDR1_LEIEN      -IEQAGNKDLGEGCDIEYRNVQFIYSARPKQVVLASVNMRFGDATSNGLIGQTGCGKSTV
MDR1_MOUSE      SYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTV
MDR1_RAT_       SYSTEGLKPNWLEGNVKFNGVKFNYPTRPNIPVLQGLSFEVKKGQTLRLVGSSGCGKSTV
MDR1_CRIGR      SYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTV
MDR1_CAEEL      SLSLAGEK-KKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTV
MDR3_HUMAN      SYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTV
MDR3_MOUSE      SYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTV
MDR3_CRIGR      SYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQGLSLEVKKGQTLALVGSSGCGKSTV
MDR3_CAEEL      NRGLTGDT-PTIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTT
                               .      * *  *    .*           .  *.* .****** 

MDR1_FUGU_      IQLLERFYDPREGRVLLDGVDVKQLNVHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSRS
MSR3_FUGU_      IQLLERFYDPREGRVSLDGVNVKQLNIHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSRS
MDR1_HUMAN      VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV
MDR1_LEIEN      IQMLARFYERRSGLISVNGRDLSSLDIAEWRRNISIVLQEPNLFSGTVRENIRYAREG--
MDR1_MOUSE      VQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRA
MDR1_RAT_       VQLLERFYNPMAGTVFLDGKEIKQLNVQCVRA-LGIVSQEPILFDCSIAENIAYGDNSRV
MDR1_CRIGR      VQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV
MDR1_CAEEL      VALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSS
MDR3_HUMAN      VQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRV
MDR3_MOUSE      VQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRV
MDR3_CRIGR      VQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLGIVSQEPVLFDCSIAENIAYGDNSRV
MDR3_CAEEL      IQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLEN--
                . .. *.*    * . .       *     *  . .* *** **  .. *** *      

MDR1_FUGU_      VSMDEIVAAAKAANIHSFIEGLPQVAAVNQGKWLIPHLIDSHGAAHDHLHHIQTVSEQRY
MSR3_FUGU_      VSMDEIR----------------------------------------------------Y
MDR1_HUMAN      VSQEEIVRAAKEANIHAFIESLP----------------------------------NKY
MDR1_LEIEN      ATDEEVEEAARLAHIHHEIIKWT----------------------------------DGY
MDR1_MOUSE      VSHEEIVRAAKEANIHQFIDSLP----------------------------------DKY
MDR1_RAT_       VSHEEIVRAAREANIHQFIDSLP----------------------------------EKY
MDR1_CRIGR      VSQDEIERAAKEANIHQFIESLP----------------------------------DKY
MDR1_CAEEL      VTMAQVEEAARLANIHNFIAELP----------------------------------EGF
MDR3_HUMAN      VSQDEIVSAAKAANIHPFIETLP----------------------------------HKY
MDR3_MOUSE      VSYEEIVRAAKEANIHQFIDSLP----------------------------------DKY
MDR3_CRIGR      VSQDEIVRAAKAANIHPFIETLP----------------------------------QKY
MDR3_CAEEL      ITQDQVEKAATLANIHTFVMGLP----------------------------------DGY
                 .  ..                                                     .

MDR1_FUGU_      DTQAGDKGTQLSGGQKQRVAIARAIIRNPKLLLLDEATSALDTESEKVVQEALD--QARK
MSR3_FUGU_      DTQAGDKGTQLSGGQKQRVAIARAIIRNPKLLLLDEATSALDTESEKVVQEALD--QARK
MDR1_HUMAN      STKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KARE
MDR1_LEIEN      DTEVGYKGRALSGGQKQRIAIARGLLRRPRLLLLDEATSALDSVTEAKVQEGIEAFQAKY
MDR1_MOUSE      NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KARE
MDR1_RAT_       NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KARE
MDR1_CRIGR      NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KARE
MDR1_CAEEL      ETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALD--RARE
MDR3_HUMAN      ETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALD--KARE
MDR3_MOUSE      NTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KARE
MDR3_CRIGR      KTRVGDKGTQLSGGQKQRLAIRRALIRQPRVLLLDEATSALDTESEKVVQEALD--KARE
MDR3_CAEEL      DTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALD--KARL
                 *  *  *  ********.** * ..* *..***********. .*  *** ..  .*. 

MDR1_FUGU_      GRTCIVVAHRLSTIQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQMGYHSG
MSR3_FUGU_      GRTCIVVAHRLSTIQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQMGYHND
MDR1_HUMAN      GRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
MDR1_LEIEN      KVTTVSIAHRLTTIRHCDQIILLDSGCIIEQGSHEELMALGGEYKTRYDLYMSALS-
MDR1_MOUSE      GRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMV--QAGAKRS
MDR1_RAT_       GRTCVVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMV--QAGAKRS
MDR1_CRIGR      GRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGAKR-
MDR1_CAEEL      GRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQMTEKK-
MDR3_HUMAN      GRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL
MDR3_MOUSE      GRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGAKRS
MDR3_CRIGR      GRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVNIQAGAQNS
MDR3_CAEEL      GRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS----
                  *.. .**** *. ..* * .   *   * *.*  *..  * *