FUGU1_MDR - Fragment 1-14000 FUGU2_MDR - Fragment 12000-26000 (2000 bp overlaps with FUGU1_MDR) MDR1_FUGU - Fragment 1-12390 MDR3_FUGU - Fragment 123711-23075 (20 bp overlap with MDR1_FUGU)
All the AA sequence are WebGene out put, not checked carefully.
My guess:
1 39551 ===================================================================================================== ^^^ ^^^ ^^^ Repaet1 Repaet 2 Repeat 3 |----------------------------| |------------------------------| |------------------------------| MDR1 MDR3 UnknownPls check
FUGU1_MDR_ ------------------------------------------------------------ FUGU2_MDR_ LLDGVDVKQLNVHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSRSVSMDEIVAAAKAANI MDR1_FUGU_ ------------------------------------------------------------ MRD3_FUGU_ ------------------------------------------------------------ MDR1_HUMAN ------------------------------------------------------------ MDR1_LEIEN ---------------------------------------------------------MSR MDR1_MOUSE ------------------------------------------------------------ MDR1_RAT_ ------------------------------------------------------------ MDR1_CRIGR ------------------------------------------------------------ MDR1_CAEEL ----------------------------------------------------MLRNGSLR MDR3_HUMAN ------------------------------------------------------------ MDR3_MOUSE ------------------------------------------------------------ MDR3_CRIGR ------------------------------------------------------------ MDR3_CAEEL ------------------------------------------------------------ FUGU1_MDR_ ---------RYDTQAGDKGTQLSGGQ---KQRVAIARAIIRNPKLLLLDEATSALDTESE FUGU2_MDR_ HSFIEGLPQRYDTQAGDKGTQLSGGQ---KQRVAIARAIIRNPKLLLLDEATSALDTESE MDR1_FUGU_ ---------RYDTQAGDKGTQLSGGQ---KQRVAIARAIIRNPKLLLLDEATSALDTENG MRD3_FUGU_ ---------RYDTQAGDKGTQLSGGQ---KQRVAIARAIIRNPKLLLLDEATSALDTERL MDR1_HUMAN ----------MDLEGDRNGGAKK------KNFFKLNNKSEKDKK--EKKPTVSVFSMFRY MDR1_LEIEN AHAAYANEGWSAPEGGIAGKDGSTRDCSGYGSQGPLFSAEEEVKGTVVRETVGPIEIFRY MDR1_MOUSE ----------MEFEENLKG-RAD------KNFSKMGKKSKKEKK--EKKPAVGVFGMFRY MDR1_RAT_ ----------MEFEEGLNG-RAD------KNFSKMGKKSKKEK---EKKPAVGIFGMFRY MDR1_CRIGR ----------MEFEEDFSG-RKD------KNFLKMGRKSKKEKK--EKKPVVSVFTMFRY MDR1_CAEEL QSLRTLDSFSLAPEDVLKTAIKTVEDYEGDNIDSNGEIKITRDAKEEVVNKVSIPQLYRY MDR3_HUMAN ----------MDLEAAKNGTAWRPTSA--EGDFELGISSKQKRKKTKTVKMIGVLTLFRY MDR3_MOUSE ----------MELEEDLKG-RAD------KNFSKMGKKSKKEKK--EKKPAVSVLTMFRY MDR3_CRIGR ----------MDLEAARNGTARRPGTV--EGDFELGSISNQGRNKKKKVNLIGPLTLFRY MDR3_CAEEL ----------------MKKTKVNP-----EDDITLGKFTPKPSP--QDSYQGNFFDVFRD FUGU1_MDR_ KVVQEALDQAR------------------------------------------------- FUGU2_MDR_ KVVQEALDQAR---------KGRTCIVVAHRLSTIQNADCIAVFQGGVVFRFADRWDVVL MDR1_FUGU_ ----WDILMVT------------------------------------------------- MRD3_FUGU_ SIMALKIDTAETNGDLSHDSKDDGAKNEKKKKNKKEKPPQEPMVGPITLFRFADRWDVVL MDR1_HUMAN SNWLDKLYMVV------------------------------------------------- MDR1_LEIEN ADATDRVLMIA------------------------------------------------- MDR1_MOUSE ADWLDKLCMIL------------------------------------------------- MDR1_RAT_ ADWLDKLCMAL------------------------------------------------- MDR1_CRIGR AGWLDRLYMLV------------------------------------------------- MDR1_CAEEL TTTLEKLLLFI------------------------------------------------- MDR3_HUMAN SDWQDKLFMSL------------------------------------------------- MDR3_MOUSE AGWLDRLYMLV------------------------------------------------- MDR3_CRIGR SDWQDKLFMLL------------------------------------------------- MDR3_CAEEL ADYKDYILFSG------------------------------------------------- . FUGU1_MDR_ --KGRTCIVVAHRLSTIQNADCIAVFQGGVVEAKLSQNHNTSN---------PSECSSAE FUGU2_MDR_ LISGTVMAMVNGTVMPLMCIVFGEMTDSFIYADMAQHNASGWNS--------TTTILNST MDR1_FUGU_ --IGVLMAIVNGLVNPLMCIVFGEMTDSFIQEAKLSQNHNTSN---------PTEFGYSN MRD3_FUGU_ LISGTVMAMVNGTVMPLMCIVFGEMTDSFIYADMAQHNASGWNS--------TTTILNST MDR1_HUMAN ---GTLAAIIHGAGLPLMMLVFGEMTDIFA--NAGNLEDLMSNITNRSDINDTGFFMN-- MDR1_LEIEN ---GTAFAVACGAGMPVFSFIFGRIAMDLMS-------------------------GVGS MDR1_MOUSE ---GTLAAIIHGTLLPLLMLVFGNMTDSFT-KAEASILPSITN---QSGPNSTLIISNSS MDR1_RAT_ ---GTLAAIIHGTLLPLLMLVFGYMTDSFTPSRDPHSDRAITN---QSEINSTHTVSDTS MDR1_CRIGR ---GTLAAIIHGVALPLMMLVFGDMTDSFA--SVGNIPTNATNN--ATQVNASDIFGK-- MDR1_CAEEL ---GTLVAVITGAGLPLMSILQGKVSQAFINEQIVINNNGSTFLP------TGQNYTKTD MDR3_HUMAN ---GTIMAIAHGSGLPLMMIVFGEMTDKFVD--------TAGNFSFPVNFSLSLLNPGKI MDR3_MOUSE ---GTLAAIIHGVALPLMMLIFGDMTDSFA--SVGNVSKNSTN---MSEADKRAMFAK-- MDR3_CRIGR ---GTIMAIAHGSGLPLMMIVFGEMTDKFVN--------NAGNFSLPVNFSLSMINPGRI MDR3_CAEEL ---GLILSAVNGALVPFNSLIFEGIANALME-----GESQYQN----------GTINMPW * . FUGU1_MDR_ EHQIMTGEQLLNQGQ---IFFNKTSQMSLWTLTAARQAKRIRELFFHGIMQQDISWYDVT FUGU2_MDR_ LQEDMQRFAIYYSVLGFVVLLAAYMQVSFWTITAGRQVKRIRSLFFHCIMQQEIS----- MDR1_FUGU_ LQPLFFRFSIYYSILGFAVLVVAYLQMSLWTLTAARQAKRIRELFFHGIMQQDISWYDVT MRD3_FUGU_ LQEDMQRFAIYYSVLGFVVLLAAYMQVSFWTITAGRQVKRIRSLFFHCIMQQEISWFDVN MDR1_HUMAN LEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVH MDR1_LEIEN AEEKAAKTSLIMVYVGIAMLIACAGHVMCWTVAACRQVARIRLLFFRAVLRQDIGWHDEH MDR1_MOUSE LEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVH MDR1_RAT_ LEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVN MDR1_CRIGR LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVH MDR1_CAEEL FEHDVMNVVWSYAAMTVGMWAAGQIIVTCYLYVAEQMNNRLRREFVKSILRQEISWFDTN MDR3_HUMAN LEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDIN MDR3_MOUSE LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVH MDR3_CRIGR LEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQNFFHAILRQEMGWFDIK MDR3_CAEEL FSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKWFDET . . . .* . . .. *. FUGU1_MDR_ ETGELNTRLTEWVTHIIHTPVPVTAGVVVIICGVRFPGAHDVYKIQEGIGDKAGLLIQAA FUGU2_MDR_ ---------------------------------------CDVYKIQEGIGDKVGLLIQAY MDR1_FUGU_ ETGELNTRLTEWVTHIIHTPVPVTAGVVVIICGVRFPGAHDVYKIQEGIGDKAGLLIQAA MRD3_FUGU_ DTGELNTRL-----------------------------TDDVYKIQEGIGDKVGLLIQAY MDR1_HUMAN DVGELNTRLT-----------------------------DDVSKINEGIGDKIGMFFQSM MDR1_LEIEN SPGALTARMT-----------------------------GDTRVIQNGINDKLSQGIMNG MDR1_MOUSE DVGELNTRLT-----------------------------DDVSKINDGIGDKIGMFFQSI MDR1_RAT_ DAGELNTRLT-----------------------------DDVSKINDGIGDKLGMFFQSI MDR1_CRIGR DVGELNTRLT-----------------------------DDVSKINEGIGDKIGMFFQAM MDR1_CAEEL HSGTLATKLF-----------------------------DNLERVKEGTGDKIGMAFQYL MDR3_HUMAN DTTELNTRLT-----------------------------DDISKISEGIGDKVGMFFQAV MDR3_MOUSE DVGELNTRLT-----------------------------DDVSKINEGIGDKIGMFFQAM MDR3_CRIGR GTTELNTRLT-----------------------------DDISKISEGIGDKVGMFFQAV MDR3_CAEEL TIGGLTQKMS-----------------------------SGIEKIKDGIGDKVGVLVGGV . * .** FUGU1_MDR_ STFITSFVIGFVHGWKLTLVILAISPVLGLSAALYSKVNISIHQW--------------- FUGU2_MDR_ TTFITAFIIGFTTGWKLTLVILAVSPALAISAAFFSKVLASFTSKEQTAYAKAGAVAEEV MDR1_FUGU_ STFITSFVIGFVHGWKLTLVILAISPVLGLSAALYSKI---------------------- MRD3_FUGU_ TTFITAFIIGFTTGWKLTLVILAVSPALAISAAFFSKVLASFTSKEQTAYAKAGAVAEEV MDR1_HUMAN ATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEV MDR1_LEIEN SMGVIGYIAGFVFSWELTLMMIGMMPFIIVMAAIIGSIVSKITESSRKYFAKAGSLATEV MDR1_MOUSE TTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEV MDR1_RAT_ TTFSAGFIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEV MDR1_CRIGR ATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEV MDR1_CAEEL SQFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEET MDR3_HUMAN ATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEA MDR3_MOUSE ATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEV MDR3_CRIGR ATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSTFSDKELAAYAKAGAVAEEA MDR3_CAEEL ATFISGVSIGFYMCWQLTLVMMITVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEV . * * ***... * FUGU1_MDR_ -----TVFAFSGQRKAIKRYHKNLEDARDMGIKKGVAANTATGFSFLMIYLSYALAFWYG FUGU2_MDR_ LSAIRTVFAFSGQTREIERYHKNLRDAKDVGVKKAISSNIAMGFTFLMIYLSYALAFWYG MDR1_FUGU_ ------------------------------------------------------------ MRD3_FUGU_ LSAIRTVFAFSGQTREIERYHKNLRDAKDVGVKKAISSNIAMGFTFLMIYLSYALAFWYG MDR1_HUMAN LAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYG MDR1_LEIEN MENIRTVQAFGREDYELERFTKAVLYAQGRGIRKELASNLSAAVIMALMYVSYTVAFFFG MDR1_MOUSE LAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYG MDR1_RAT_ LAAIRTVIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYALAFWYG MDR1_CRIGR LAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYG MDR1_CAEEL ISSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIG MDR3_HUMAN LGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYG MDR3_MOUSE LAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYG MDR3_CRIGR LGAIRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYG MDR3_CAEEL IAGIRTVMAFNAQPFEINRYAHQLNEARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYG FUGU1_MDR_ TTLVLNKEYTIGNLLTVFFVVLYGAYIIGQASPNVQSFASARGAAYKVY----NIID--- FUGU2_MDR_ STLILNFEYTIGNLLTVFFVVLIGAFSVGQTSPNIQNFASARGAAYKVYSIIDNTGS--- MDR1_FUGU_ ------------------------------------------------------------ MRD3_FUGU_ STLILNFEYTIGNLLTVFFVVLIGAFSVGQTSPNIQNFASARGAAYKVYSIIDNVRRPLD MDR1_HUMAN TTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPS--- MDR1_LEIEN SYLVEWGRRDMADIISTFLAVLMGSFGLGFVAPSRTAFTESRAAAYEIFKAIDRVPP--- MDR1_MOUSE TSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPS--- MDR1_RAT_ TSLVLSNEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIIDNEPS--- MDR1_CRIGR TSLVISKEYSIGQVLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPS--- MDR1_CAEEL VGWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKP---- MDR3_HUMAN STLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPK--- MDR3_MOUSE TSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPS--- MDR3_CRIGR STLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPK--- MDR3_CAEEL ATLAAAGAVSSGAVFAVFWAVLIGTRRLGEAAPHLGAITGARLAIHDIFKVIDHEPE--- FUGU1_MDR_ ------------------------------------------------------------ FUGU2_MDR_ -----------------------DGRLS-------------------------------- MDR1_FUGU_ ------------------------------------------------------------ MRD3_FUGU_ PGLVIILLKLASLLLEACRSVLVTARVSTWALWESALMQREDGFKPDFIKGDIEFKNIHF MDR1_HUMAN -----------------------IDSYS------------KSGHKPDNIKGNLEFRNVHF MDR1_LEIEN -----------------------VDIDAG-------------GVPVPGFKESIEFRNVRF MDR1_MOUSE -----------------------IDSFS------------TKGYKPDSIMGNLEFKNVHF MDR1_RAT_ -----------------------IDSFS------------TKGHKPDSIMGNLEFKNVYF MDR1_CRIGR -----------------------IDSFS------------KNGYKPDNIKGNLEFKNIHF MDR1_CAEEL ----------------------VIDSSS------------KAGRKDMKIKGDITVENVHF MDR3_HUMAN -----------------------IDSFS------------ERGHKPDSIKGNLEFNDVHF MDR3_MOUSE -----------------------IDSFS------------KSGHKPDNIQGNLEFKNIHF MDR3_CRIGR -----------------------IDSFS------------ERGHKPDSIKGNLDFSDVHF MDR3_CAEEL -----------------------IKCTS------------SEGKIPEKIQGKLTFDGIEF FUGU1_MDR_ ----H----ILNDMSFHVRNGQTIALVGSSGCGKSTTIQLLQRFYDPQKGSVNVRPHLWL FUGU2_MDR_ ------HLQILNNMSLSVKSGQTIALVGSSGCGKSTTIQLLQRFYDPEEGAVFIDGHDIR MDR1_FUGU_ ----------LNDMSFHVRNGQTIALVGSSGCGKSTTIQLLQRFYDPQKG---------- MRD3_FUGU_ NYPSRPEVKILNNMSLSVKSGQTIALVGSSGCGKSTTIQLLQRFYDPEEGAVFIDGHDIR MDR1_HUMAN SYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIR MDR1_LEIEN AYPTRPGMILFRDLSLKIKCGQKVAFSGASGCGKSSVIGLIQRFYDPIGGAVLVDGVRMR MDR1_MOUSE NYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVVSIDGQDIR MDR1_RAT_ NYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIR MDR1_CRIGR SYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVVSIDGQDIR MDR1_CAEEL TYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVR MDR3_HUMAN SYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIR MDR3_MOUSE SYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIR MDR3_CRIGR SYPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDPTEGTISIDGQDIR MDR3_CAEEL TYPTRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQ . . *. .* * *****.. . *. * * * FUGU1_MDR_ PY--------------------------------------LSLAPSRSNANIYIMISEQK FUGU2_MDR_ SLNIRYLREMIGVVSQEPVLFATTITENIRYGRLDVTQEEIERATKESNAYDFIMNLPDK MDR1_FUGU_ ----------------------------------------------------------SK MRD3_FUGU_ SLNIRYLREMIGVVSQEPVLFATTITENIRYGRLDVTQEEIERATKESNAYDFIMNLPDK MDR1_HUMAN TINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHK MDR1_LEIEN ELCLREWRDQIGIVSQEPNLFAGTMMENVRMGKPNATDEEVVEACRQANIHDTIMALPDR MDR1_MOUSE TINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQ MDR1_RAT_ TINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHK MDR1_CRIGR TINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHK MDR1_CAEEL DINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIKTLPNG MDR3_HUMAN NFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQK MDR3_MOUSE TINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQ MDR3_CRIGR NFNVRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKAVKEANAYEFIMKLPQK MDR3_CAEEL EYNIRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDR FUGU1_MDR_ FETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVQTQ FUGU2_MDR_ FETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVQTQ MDR1_FUGU_ FETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVQTQ MRD3_FUGU_ FETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDK---- MDR1_HUMAN FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDK---- MDR1_LEIEN YDTPVGPVGSLLSGGQKQRIAIARALVKRPPILLLDEATSALDRKSEMEVQAALDQLIQ- MDR1_MOUSE FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDK---- MDR1_RAT_ FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDK---- MDR1_CRIGR FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDK---- MDR1_CAEEL YNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDK---- MDR3_HUMAN FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDK---- MDR3_MOUSE FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDK---- MDR3_CRIGR FDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDK---- MDR3_CAEEL YDTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDK---- . * .* ********.*****.*. * ************ ** ** ***. FUGU1_MDR_ T------RAEMMGNKETLLHCLLVYVSPFMVRLGRTTIVIAHRLSTIRNADIIAGFSNG- FUGU2_MDR_ TCSPSPCRTQPLDLKDISQYGQYVFSG---VRLGRTTIVVAHRLSTIRNADIIAGFSNG- MDR1_FUGU_ T------RAEMMGNKETLLHCLLVYVSPFMVRLGRTTIVIAHRLSTIRNADIIAGFSNG- MRD3_FUGU_ ------------------------------VRLGRTTIVVAHRLSTIRNADIIAGFSNG- MDR1_HUMAN ------------------------------ARKGRTTIVIAHRLSTVRNADVIAGFDDG- MDR1_LEIEN -------------------------------RGGTTVVVIAHRLATIRDMDRIYYVKHDG MDR1_MOUSE ------------------------------AREGRTTIVIAHRLSTVRNADVIAGFDGG- MDR1_RAT_ ------------------------------AREGRTTIVIAHRLSTVRNADVIAGFDGG- MDR1_CRIGR ------------------------------AREGRTTIVIAHRLSTVRNADIIAGFDGG- MDR1_CAEEL ------------------------------AAKGRTTIIIAHRLSTIRNADLIISCKNG- MDR3_HUMAN ------------------------------AREGRTTIVIAHRLSTVRNADVIAGFEDG- MDR3_MOUSE ------------------------------AREGRTTIVIAHRLSTVRNADVIAGFDGG- MDR3_CRIGR ------------------------------AREGRTTIVIAHRLSTVRNADVIAGFEDG- MDR3_CAEEL ------------------------------ASEGRTTLCIAHRLSTIRNASTHDELIS-- * * . .****.*.* FUGU1_MDR_ ----EIVEQGTHSQLMEIKGVYHGLVTMQSFQK-LEDLEDSDYEPW------VAEKSQLI FUGU2_MDR_ ----KIVEQGTHSQLMEIKGVYHGLVTMQTFHN-VEEENTAMSELS------AGEKSPVE MDR1_FUGU_ ----EIVEQGTHSQLMEIKGVYHGLVTMQSFQK-LEDLEDSDYEPW------VAEKSQLI MRD3_FUGU_ ----KIVEQGTHSQLMEIKGVYHGLVTMQTFHN-VEEENTAMSELS------AGEKSPVE MDR1_HUMAN ----VIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKS------EIDALEMS MDR1_LEIEN AEGSRITESGTFDELLELDGEFAAVAKMQGVLAGDAKSGASVRDAK-----KASGHLGVI MDR1_MOUSE ----VIVEQGNHDELMREKGIYFKLVMTQTRGNEIEPGNNAYGSQS------DTDASELT MDR1_RAT_ ----VIVEQGNHEELMKEKGIYFKLVMTQTRGNEIEPGNNAYESQS------DTGASELT MDR1_CRIGR ----VIVEQGNHEELMREKGIYFKLVMTQTAGNEIELGNEVGESKN------EIDNLDMS MDR1_CAEEL ----QVVEVGDHRALMAQQGLYYDLVTAQTFTDAVDSAAEGKFSRENSVARQTSEHEGLS MDR3_HUMAN ----VIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELND--------EKAATRMA MDR3_MOUSE ----VIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACKSKD------EIDNLDMS MDR3_CRIGR ----VIVEQGSHSELMQKEGVYFKLVNMQTSGSQILSQEFEVELSE------EKAADGMT MDR3_CAEEL ------KDDGIYASMVKAQEIERAKEDTTLDDEEDEKTHRSFHRDS----VTSDEERELQ . * .. . FUGU1_MDR_ ESFSQSSLQRRRSTRGSLLAVSEGTKEEKEK---FECDQD----NIEEDENVPPVSFFKV FUGU2_MDR_ KTVSQSSIIRRKSTRGSSFAAQVLHSGDNIDGYYTSCVPDYSPIYTLRDEDVPDVSFFKV MDR1_FUGU_ ESFSQSSLQRRRSTRGSLLAVSEGTKEEKEK---FECDQD----NIEEDENVPPVSFFKV MRD3_FUGU_ KTVSQSSIIRRKSTRGSSFAASEGTK-EE---------------KTEEDEDVPDVSFFKV MDR1_HUMAN SNDSRSSLIRKRSTRRSVRGSQAQDRKLSTK--------------EALDESIPPVSFWRI MDR1_LEIEN LDEADLAQLDEDVPRTARQNVPIDEL-------------------AKWEVKHAKVGFLRL MDR1_MOUSE SEESKSPLIR-RSIYRSVHRKQDQERRLSMK--------------EAVDEDVPLVSFWRI MDR1_RAT_ SEESKSPLIR-RSIRRSIHRRQDQERRLSSK--------------EDVDEDVPMVSFWQI MDR1_CRIGR SKDSASSLIRRRSTRRSIRGPHDQDRKLSTK--------------EALDEDVPPISFWRI MDR1_CAEEL RQASEMDDIMNRVRSSTIGSITNGPVIDEKEER-IGKDALSRLKQELEENNAQKTNLFEI MDR3_HUMAN PNGWKSRLFR-HSTQKNLKNSQMCQKSLDVET-------------DGLEANVPPVSFLKV MDR3_MOUSE SKDSGSSLIRRRSTRKSICGPHDQDRKLSTK--------------EALDEDVPPASFWRI MDR3_CRIGR PNGWKSHIFR-NSTKKSLKSSRAHHHRLDVDA-------------DELDANVPPVSFLKV MDR3_CAEEL QSLARDSTRLRQSMISTTTQVPEWEIENARE--------------EMIEEGAMEASLFDI . . FUGU1_MDR_ MRYNVSEWPYILVGTICAMINGAMQPVFSIIFTEIIMVF---REKDK-EIIREKSSFFCI FUGU2_MDR_ LHLNIPEWPYILVGLICATINGAMQPVFAILFSKIITVD---RDS----V-RRKSEFISL MDR1_FUGU_ MRYNVSEWPYILVGTICAMINGAMQPVFSIIFTEIIMAA--------------------- MRD3_FUGU_ LHLNIPEWPYILVGLICATINGAMQPVFAILFSKIIT----------------------- MDR1_HUMAN MKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVF---TRIDDPETKRQNSNLFSL MDR1_LEIEN MRMNKDKAWAVALGILSSVVIGSARPASSIVMGHMLRVLGEYSATKDVEALRSGTNLYAP MDR1_MOUSE LNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVF---SRDDDHETKRQNCNLFSL MDR1_RAT_ LKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVF---SRDDDHETKQRNCNLFSL MDR1_CRIGR LKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVF---TRNTDDETKRHDSNLFSL MDR1_CAEEL LYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFMNVF---AGN--PADFLSQGHFWAL MDR3_HUMAN LKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIF---GPGDD-AVKQQKCNIFSL MDR3_MOUSE LKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVF---TNGGPPETQRQNSNLFSL MDR3_CRIGR LKLNKTEWPYFVVGTVCAIVNGALQPAISIILSEMIAIF---GPGDD-AVKQQKCNLFSL MDR3_CAEEL FKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKIL---SAGGD--DVSIKALLNSL . . * * .. FUGU1_MDR_ LFAVMGVVTFLTMFLQGFCFSKSGEILTLNLRLKAFISMMRQDLSWYDNPKNTVGALTTR FUGU2_MDR_ MFVVIGCVSFVTMFLQ--------------------------DLSWYDNPQNTVGALTTR MDR1_FUGU_ ------------------------------------------------------------ MRD3_FUGU_ ------------------------------------------DLSWYDNPQNTVGALTTR MDR1_HUMAN LFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTR MDR1_LEIEN LFIVFAVANFSGWILHG-FYGYAGEHLTTKIRVLLFRQIMRQDINFFDIPGRDAGTLAGM MDR1_MOUSE FFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTTR MDR1_RAT_ LFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTTR MDR1_CRIGR LFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTR MDR1_CAEEL MFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKISTR MDR3_HUMAN IFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTR MDR3_MOUSE LFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTR MDR3_CRIGR VFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGALSTR MDR3_CAEEL WFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTSR FUGU1_MDR_ LAADAAHVQGAAGVRLAVMTQNFANLGTSIIIS--FVYGWELTLLILAVVPILAVAGAAE FUGU2_MDR_ LAADAAQVQGAAGVRLATIMQNFANLGTSIIIA--FVYGWELTLLILAVVPLIAAAGAAE MDR1_FUGU_ ------------GVRLAVMTQNFANLGTSIIIS--FVYGWELTLLILAVVPILAVAGAAE MRD3_FUGU_ LAADAAQVQGAAGVRLATIMQNFANLGTSIIIA--FVYGWELTLLILAVVPLIAAAGAAE MDR1_HUMAN LANDAAQVKGAIGSRLAVITQNIANLGTGIIIS--FIYGWQLTLLLLAIVPIIAIAGVVE MDR1_LEIEN LSGDCEAVHQLWGPSIGLKVQTMCIIASGLVVG--FIYQWKLALVALACMPLMIGCSLTR MDR1_MOUSE LASDASSVKGAMGARLAVVTQNVANLGTGVILS--LVYGWQLTLLLVVIIPLIVLGGIIE MDR1_RAT_ LASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTLLLVVIIPLIVLGGIIE MDR1_CRIGR LANDAGQVKGATGARLAVITQNIANLGTGIIIS--LIYGWQLTLLLLAIVPIIAIAGVVE MDR1_CAEEL LATDVPNLRTAIDFRFSTVITTLVSMVAGIGLA--FFYGWQMALLIIAILPIVAFGQYLR MDR3_HUMAN LATDAAQVQGATGTRLALIAQNIANLGTGIIIS--FIYGWQLTLLLLAVVPIIAVSGIVE MDR3_MOUSE LANDAAQVKGATGSRLAVIFQNIANLGTGIIIS--LIYGWQLTLLLLAIVPIIAIAGVVE MDR3_CRIGR LATDRAQVQGATGTRLALIAQNTANLGTGIIIS--FIYGWQLTLLLLSVVPFIAVSGIVE MDR3_CAEEL LATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVA--FYYGWNMAPIGLATELLLVVVQSSV . . . . * * .. . . . FUGU1_MDR_ VKLLTGHAAEDKKELEMAGKIATEAIEN-------------VRTVCFLITFFLTLRRNSQ FUGU2_MDR_ IKLLAGHAAKDKKELEKAGKVELKRVKFDLLQGCHCGIRKNKSVVSPCRSPQRPSRTNSQ MDR1_FUGU_ VKLLTGHAAEDKKELEMAG----------------------------------------- MRD3_FUGU_ IKLLAGHAAKDKKELEKAGKIATEAIEN--VRTVVSLSREPK-FECLYEENLRVPYKNSQ MDR1_HUMAN MKMLSGQALKDKKELEGAGKIATEAIEN--FRTVVSLTQEQK-FEHMYAQSLQVPYRNSL MDR1_LEIEN RLMINGYTKS--REGDTDDTIVTEALSN--VRTVTSLNMKEDCVEA-FQAALREEAPRSV MDR1_MOUSE MKLLSGQALKDKKQLEISGKIATEAIEN--FRTIVSLTREQK-FETMYAQSLQVPYRNAM MDR1_RAT_ MKLLSGQALKDKKELEISGKIATEAIEN--FRTVVSLTREQK-FETMYAQSLQIPYRNAL MDR1_CRIGR MKMLSGQALKDKKELEGSGKIATEAIEN--FRTVVSLTREQK-FENMYAQSLQIPYRNAL MDR1_CAEEL GRRFTGKNVKSASEFADSGKIAIEAIEN--VRTVQALAREDTFYEN-FCEKLDIPHKEAI MDR3_HUMAN MKLLAGNAKRDKKELEAAGKIATEAIEN--IRTVVSLTQERK-FESMYVEKLYGPYRNSV MDR3_MOUSE MKMLSGQALKDKKELEGSGKIATEAIEN--FRTVVSLTREQK-FETMYAQSLQIPYRNAM MDR3_CRIGR MKMLAGNAKRDKKALEAAGKIATEAIEN--IRTVVSLTQERK-FESMYVEKLHEPYRNSV MDR3_CAEEL AQYLKFRGQRDMDSAIEASRLVTESISN--WKTVQALTKQEYMYDAFTAAS-KSPHRRAI FUGU1_MDR_ KKAKIYGLTYSFSQAMIFFVYAACFRFGAWLIEAG--RMDVEGVFLVVMTMLYGAMAVGE FUGU2_MDR_ KKAHVYGLTYSFSQAMIYFAYAACFRFGAWLIEAG--RMDVEGVFLVVSAVLYGAMAVGE MDR1_FUGU_ ------------------------------------------------------------ MRD3_FUGU_ KKAHVYGLTYSFSQAMIYFAYAACFRFGAWLIEAG--RMDVEGVFLVVSAVLYGAMAVGE MDR1_HUMAN RKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK--LMSFEDVLLVFSAVVFGAMAVGQ MDR1_LEIEN RKGIIAGGIYGITQFIFYGVYALCFWYGSKLIDKG--EAEFKDVMIASMSILFGAQNAGE MDR1_MOUSE KKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQ--LMTFENVMLVFSAVVFGAMAAGN MDR1_RAT_ KKAHVFGITFAFTQAMIYFSYAACFRFGAYLVARE--LMTFENVMLVFSAVVFGAMAAGN MDR1_CRIGR KKAHVFGITFSFTQAMMYFSYAACFRFGAYLVARE--LMTFENVLLVFSAIVFGAMAVGQ MDR1_CAEEL KEAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGF MDR3_HUMAN QKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNG--HMRFRDVILVFSAIVFGAVALGH MDR3_MOUSE KKAHVFGITFFFTQAMMYFSYAACFRFGAYLVTQQ--LMTFENVLLVFSAIVFGAMAVGQ MDR3_CRIGR QMAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNG--HMRFRDVILVFSAIVFGAVALGH MDR3_CAEEL VRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNN--WSTPYTVFQVIEALNMASMSVML FUGU1_MDR_ ANTYAPNFAKAKISASHLTMLINRQPAIDNLSEEEARLEKYDGNVLFEDVKFNYPSRPDV FUGU2_MDR_ ANTFAPNYAKAKMAASYLMMLINKKPAIDNLSEEGTSPEKYDGNVHFEGVKFNYPSRPDV MDR1_FUGU_ ------------K-------------------E------KYDGNVLFEDVKFNYPSRPDV MRD3_FUGU_ ANTFAPNYAKAKMAASYLMMLINKKPAIDNLSEEGTSPEKYDGNVHFEGVKFNYPSRPDV MDR1_HUMAN VSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDI MDR1_LEIEN AGAFATKLADAEASAKRVFSVIDRVPDVD-IEQAGNKDLGEGCDIEYRNVQFIYSARPKQ MDR1_MOUSE TSSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNI MDR1_RAT_ TSSFAPDYAKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPNI MDR1_CRIGR VSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDI MDR1_CAEEL ATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEK-KKLYGKVIFKNVRFAYPERPEI MDR3_HUMAN ASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV MDR3_MOUSE VSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYPTRPSI MDR3_CRIGR ASSFAPDYAKAKLSAAHLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANM MDR3_CAEEL AASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTP-TIKGNINMRGVYFAYPNRRRQ . * * * FUGU1_MDR_ PVLQGLNLEVQKGETLALVGSSGCGKSTTIQLLERFYDPREGRVIMSQAELGDLSQLRSS FUGU2_MDR_ TILQGLNLKVKKGETLALVGSSGCGKSTTIQLLERFYDPREG------------------ MDR1_FUGU_ PVLQGLNLEVQKGETLALVGSSGCGKSTTIQLLERFYDPREG------------------ MRD3_FUGU_ TILQGLNLKVKKGETLALVGSSGCGKSTTIQLLERFYDPREG------------------ MDR1_HUMAN PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG------------------ MDR1_LEIEN VVLASVNMRFGDATSNGLIGQTGCGKSTVIQMLARFYERRSG------------------ MDR1_MOUSE PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAG------------------ MDR1_RAT_ PVLQGLSFEVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAG------------------ MDR1_CRIGR PVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAG------------------ MDR1_CAEEL EILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGG------------------ MDR3_HUMAN PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG------------------ MDR3_MOUSE PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAG------------------ MDR3_CRIGR PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAG------------------ MDR3_CAEEL LVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCG------------------ .* . *.* .****** . .. *.* * FUGU1_MDR_ HAFSTLPTVYERRDMIIGLLQVHKLLDGVDVKQLNVHWLRSQIGIVSQEP---------- FUGU2_MDR_ ------------R----------VSLDGVNVKQLNIHWLRSQIGIVSQEPRYDTQAGDKG MDR1_FUGU_ ------------R----------VLLDGVDVKQLNVHWLRSQIGIVSQEP---------- MRD3_FUGU_ ------------R----------VSLDGVNVKQLNIHWLRSQIGIVSQEP---------- MDR1_HUMAN ----------------------KVLLDGKEIKRLNVQWLRAHLGIVSQEP---------- MDR1_LEIEN ----------------------LISVNGRDLSSLDIAEWRRNISIVLQEP---------- MDR1_MOUSE ----------------------SVFLDGKEIKQLNVQWLRAHLGIVSQEP---------- MDR1_RAT_ ----------------------TVFLDGKEIKQLNVQCVRA-LGIVSQEP---------- MDR1_CRIGR ----------------------TVFLDGKEVNQLNVQWLRAHLGIVSQEP---------- MDR1_CAEEL ----------------------EIFIDGSEIKTLNPEHTRSQIAIVSQEP---------- MDR3_HUMAN ----------------------TVLLDGQEAKKLNVQWLRAQLGIVSQEP---------- MDR3_MOUSE ----------------------SVFLDGKEIKQLNVQWLRAQLGIVSQEP---------- MDR3_CRIGR ----------------------TVLLDGQEAKKLNIQWLRAQLGIVSQEP---------- MDR3_CAEEL ----------------------SVKIDDSDIRDLSVKHLRDNIALVGQEP---------- . * * . .* *** FUGU1_MDR_ VLFDCSLAENIAYG----DNSRSVSMDEIVAAAKAANIHSFIEGLPQRYDTQAGDKGTQL FUGU2_MDR_ TQLSGGQKQRVAIARAIIRNPKLLLLDEATSALDTE------------------------ MDR1_FUGU_ VLFDCSLAENIAYG----DNSRSVSMDEIVAAAKAANIHSFIEGLPQVAA---------- MRD3_FUGU_ VLFDCSLAENIAYG----DNSRSVSMDEIVACC--------------------------- MDR1_HUMAN ILFDCSIAENIAYG----DNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQL MDR1_LEIEN NLFSGTVRENIRYA------REGATDEEVEEAARLAHIHHEIIKWTDGYDTEVGYKGRAL MDR1_MOUSE ILFDCSIAENIAYG----DNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQL MDR1_RAT_ ILFDCSIAENIAYG----DNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQL MDR1_CRIGR ILFDCSIAENIAYG----DNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQL MDR1_CAEEL TLFDCSIAENIIYG----LDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQL MDR3_HUMAN ILFDCSIAENIAYG----DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQL MDR3_MOUSE ILFDCSIAENIAYG----DNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQL MDR3_CRIGR VLFDCSIAENIAYG----DNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGTQL MDR3_CAEEL TLFNLTIRENITYG------LENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRL . . . . FUGU1_MDR_ SGGQKQRVAIARAIIRNPKLLLLDEATSALDTESEKVVQEALD--QARKGRTCIVVAHRL FUGU2_MDR_ -------------------------S--------EKVVQEALD--QARKGRTCIVVAHRL MDR1_FUGU_ ------------------------------------------------------------ MRD3_FUGU_ ------------------------------------------------------------ MDR1_HUMAN SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KAREGRTCIVIAHRL MDR1_LEIEN SGGQKQRIAIARGLLRRPRLLLLDEATSALDSVTEAKVQEGIEAFQAKYKVTTVSIAHRL MDR1_MOUSE SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KAREGRTCIVIAHRL MDR1_RAT_ SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KAREGRTCVVIAHRL MDR1_CRIGR SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KAREGRTCIVIAHRL MDR1_CAEEL SGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALD--RAREGRTCIVIAHRL MDR3_HUMAN SGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALD--KAREGRTCIVIAHRL MDR3_MOUSE SGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KAREGRTCIVIAHRL MDR3_CRIGR SGGQKQRLAIRRALIRQPRVLLLDEATSALDTESEKVVQEALD--KAREGRTCIVIAHRL MDR3_CAEEL SGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALD--KARLGRTCVVIAHRL FUGU1_MDR_ STIQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQMGYHSG FUGU2_MDR_ STIQNADCIAVFQGGVVVEKGTHQQLIAKKGVYHMLVTKQMGYHND MDR1_FUGU_ ---------------------------------------------- MRD3_FUGU_ ---------------------------------------------- MDR1_HUMAN STIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ MDR1_LEIEN TTIRHCDQIILLDSGCIIEQGSHEELMALGGEYKTRYDLYMSALS- MDR1_MOUSE STIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMV--QAGAKRS MDR1_RAT_ STIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMV--QAGAKRS MDR1_CRIGR STIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGAKR- MDR1_CAEEL NTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQMTEKK- MDR3_HUMAN STIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL MDR3_MOUSE STIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGAKRS MDR3_CRIGR STIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVNIQAGAQNS MDR3_CAEEL STIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS----